Azelaic acid

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         Sir myself Dipti Bele student of Mtech cosmetics from India. Iam serching for assy procedure of azelaic acid . If u have it please try to send me on my Email ID     &n...
by Dipti Bele in INDIA, 08/29/2007

Azelaic acid
Azelaic acid (Azelex)
Azelaic acid
(ah-zih- LAY-ic ah- SID)
Pregnancy Category: B Azelex (Rx)

Classification: Antiacne drug

Action/Kinetics: The precise mechanism of action in treating acne is not known, but the drug possesses antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Causes a decrease in the thickness of the stratum corneum, a reduction in the number and size of keratohyalin granules, and a reduction in the amount and distribution of filaggrin in epidermal layers. After application, the drug penetrates to the stratum corneum, epidermis, and dermis. A small amount of the drug (4%) is absorbed into the systemic circulation.

Uses: Treatment of mild to moderate inflammatory acne vulgaris.

Contraindications: Ophthalmic use.

Special Concerns: Use with caution during lactation. Safety and efficacy have not been determined in children less than 12 years of age.

Side Effects: Dermatologic: Pruritus, burning, stinging, tingling, erythema, dryness, rash, peeling, irritation, dermatitis, contact dermatitis, vitiligo depigmentation, small depigmented spots, hypertrichosis, reddening (sign of keratosis pilaris), exacerbation of recurrent herpes labialis (rare). Miscellaneous: Worsening of asthma, allergic reactions.

How Supplied: Cream: 20%

?Cream Acne vulgaris.
Gently but thoroughly massage a thin film into the affected areas b.i.d., in the morning and evening, after the skin is thoroughly washed and patted dry.

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