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azathioprine to replace prednison therapy

Dr put me on  Azathioprine to replace prednisone, how does this affect my imune system? whe asked how long I would be on this he said til you die........ Have  no or never had caancer,  Am concerned with this therapy, could y ou explain...
by Jackie Abrams in Wellton, Arizona, 02/12/2009

Can Azathioprine be taken in pregancy

A known case of RA since 15 years. The case is in the exacerabative phase right now. The age of the patient is 35 years. She is on Methotrixate, Prednisolone, Hydroxychloroquine. She is also a known case of Alpha-thalassemia (minor). Patient is willin...
by Dr. Ketaki bhatlawande in Pune, India, 02/26/2006


I am taking 100 mg daily Azathioprine for treatment of Crohn's.  I have gained substancial amount of weight since taking this drug.  What can I do to keep the weight gain off as I will have to continue taking this drug indefinately. &nbs...
by Sharon Call in Omaha, NE, 06/09/2009

what are the side effects of taking azathioprine during pregnancy

what are the side effeces of taking azathioprine 50mg x2 der day during pregnancy
by Regina Padden in UK, 10/22/2006

Azathioprine (Imuran)
(ay-zah- THIGH-oh-preen)
Pregnancy Category: D Gen-Azathioprine Imuran (Rx)

Classification: Immunosuppressant

Action/Kinetics: Antimetabolite that is quickly split to form mercaptopurine. To be effective, the drug must be given during the induction period of the antibody response. The precise mechanism in depressing the immune response is unknown, but it suppresses cell-mediated hypersensitivities and alters antibody production. Inhibits synthesis of DNA, RNA, and proteins and may interfere with meiosis and cellular metabolism. The mechanism for its effect on autoimmune diseases is not known. Is readily absorbed from the GI tract. The anuric client manifests increased effectiveness and toxicity (up to twofold). Onset: 6-8 weeks for rheumatoid arthritis. t 1/2: 3 hr.

Uses: As an adjunct to prevent rejection in renal homotransplantation. In adult clients meeting criteria for classic or definite rheumatoid arthritis as defined by the American Rheumatism Association. Restrict use to clients with severe, active, and erosive disease that is not responsive to conventional therapy. Investigational: Chronic ulcerative colitis, generalized myasthenia gravis, to control the progression of Behçet's syndrome (especially eye disease), Crohn's disease (low doses).

Contraindications: Treatment of rheumatoid arthritis in pregnancy or in clients previously treated with alkylating agents. Pregnancy and lactation.

Special Concerns: Hematologic toxicity is dose-related and may occur late in the course of therapy; may be more severe in renal transplant clients undergoing rejection. Although used in children, safety and efficacy have not been established.

Side Effects: Hematologic: Leukopenia, thrombocytopenia, macrocytic anemia, severe bone marrow depression selective erythrocyte aplasia. GI: N&V, diarrhea, abdominal pain, steatorrhea. CNS: Fever, malaise. Other: Increased risk of carcinoma severe infections (fungal, viral, bacterial, and protozoal), and hepatotoxicity are major side effects. Also, skin rashes, alopecia, myalgias, increase in liver enzymes, hypotension, negative nitrogen balance.

Overdose Management: Symptoms: Large doses may result in bone marrow hypoplasia bleeding, infection, and death. Treatment: Approximately 45% can be removed from the body following 8 hr of hemodialysis.

Drug Interactions: ACE inhibitors / Risk of severe leukopenia Allopurinol / Pharmacologic effect of azathioprine R/T liver breakdown Anticoagulants / Anticoagulant effect Corticosteroids / With azathioprine, may cause muscle wasting after prolonged therapy Cyclosporine / Plasma cyclosporine levels Echinacea / Do not give with azathioprine Methotrexate / Plasma levels of the active metabolite, 6-mercaptopurine Tubocurarine / Tubocurarine effect and other nondepolarizing neuromuscular blocking agents

How Supplied: Powder For Injection: 100 mg; Tablet: 50 mg

?Tablets, IV Use in renal homotransplantation.
Adults and children, initial: 3-5 mg/kg (120 mg/m 2), 1-3 days before or on the day of transplantation; maintenance: 1-3 mg/kg (45 mg/m 2) daily.
Rheumatoid arthritis, SLE.
Adults and children, tablets, initial: 1 mg/kg (50-100 mg); then, increase dose by 0.5 mg/kg/day after 6-8 weeks and thereafter q 4 weeks, up to maximum of 2.5 mg/kg/day; maintenance: lowest effective dose. Dosage should be reduced in clients with renal dysfunction.
Myasthenia gravis.
2-3 mg/kg/day. However, side effects occur in more than 35% of clients.
To control progression of Behçet's syndrome.
2.5 mg/kg/day.
To treat Crohn's disease.
75-100 mg/day.

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