Azathioprine


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Most QuotesChimp don't realize how deeply government is involved with insurance. The federal government has several insurance plans ranging from Social Security and Medicare to the Federal Deposit Insurance Corporation and the Veterans Administration....
by Adele in Adele, 03/06/2014

azathioprine to replace prednison therapy


Dr put me on  Azathioprine to replace prednisone, how does this affect my imune system? whe asked how long I would be on this he said til you die........ Have  no or never had caancer,  Am concerned with this therapy, could y ou explain...
by Jackie Abrams in Wellton, Arizona, 02/12/2009

I have had Crohn's D


I have had Crohn's Disease for 20 years. I've had 3 surgeries on my small and large innsteites and one fiscula. I have been sick for so long and it never stops permanently. Right now I take Remicade treatments 15mg every 8 weeks. It does help me to ha...
by Consuelo in Consuelo, 01/14/2014

Can Azathioprine be taken in pregancy


A known case of RA since 15 years. The case is in the exacerabative phase right now. The age of the patient is 35 years. She is on Methotrixate, Prednisolone, Hydroxychloroquine. She is also a known case of Alpha-thalassemia (minor). Patient is willin...
by Dr. Ketaki bhatlawande in Pune, India, 02/26/2006

Azathioprine


I am taking 100 mg daily Azathioprine for treatment of Crohn's.  I have gained substancial amount of weight since taking this drug.  What can I do to keep the weight gain off as I will have to continue taking this drug indefinately. &nbs...
by Sharon Call in Omaha, NE, 06/09/2009

Azathioprine
Azathioprine (Imuran)
Azathioprine
(ay-zah- THIGH-oh-preen)
Pregnancy Category: D Gen-Azathioprine Imuran (Rx)

Classification: Immunosuppressant

Action/Kinetics: Antimetabolite that is quickly split to form mercaptopurine. To be effective, the drug must be given during the induction period of the antibody response. The precise mechanism in depressing the immune response is unknown, but it suppresses cell-mediated hypersensitivities and alters antibody production. Inhibits synthesis of DNA, RNA, and proteins and may interfere with meiosis and cellular metabolism. The mechanism for its effect on autoimmune diseases is not known. Is readily absorbed from the GI tract. The anuric client manifests increased effectiveness and toxicity (up to twofold). Onset: 6-8 weeks for rheumatoid arthritis. t 1/2: 3 hr.

Uses: As an adjunct to prevent rejection in renal homotransplantation. In adult clients meeting criteria for classic or definite rheumatoid arthritis as defined by the American Rheumatism Association. Restrict use to clients with severe, active, and erosive disease that is not responsive to conventional therapy. Investigational: Chronic ulcerative colitis, generalized myasthenia gravis, to control the progression of Behçet's syndrome (especially eye disease), Crohn's disease (low doses).

Contraindications: Treatment of rheumatoid arthritis in pregnancy or in clients previously treated with alkylating agents. Pregnancy and lactation.

Special Concerns: Hematologic toxicity is dose-related and may occur late in the course of therapy; may be more severe in renal transplant clients undergoing rejection. Although used in children, safety and efficacy have not been established.

Side Effects: Hematologic: Leukopenia, thrombocytopenia, macrocytic anemia, severe bone marrow depression selective erythrocyte aplasia. GI: N&V, diarrhea, abdominal pain, steatorrhea. CNS: Fever, malaise. Other: Increased risk of carcinoma severe infections (fungal, viral, bacterial, and protozoal), and hepatotoxicity are major side effects. Also, skin rashes, alopecia, myalgias, increase in liver enzymes, hypotension, negative nitrogen balance.

Overdose Management: Symptoms: Large doses may result in bone marrow hypoplasia bleeding, infection, and death. Treatment: Approximately 45% can be removed from the body following 8 hr of hemodialysis.

Drug Interactions: ACE inhibitors / Risk of severe leukopenia Allopurinol / Pharmacologic effect of azathioprine R/T liver breakdown Anticoagulants / Anticoagulant effect Corticosteroids / With azathioprine, may cause muscle wasting after prolonged therapy Cyclosporine / Plasma cyclosporine levels Echinacea / Do not give with azathioprine Methotrexate / Plasma levels of the active metabolite, 6-mercaptopurine Tubocurarine / Tubocurarine effect and other nondepolarizing neuromuscular blocking agents

How Supplied: Powder For Injection: 100 mg; Tablet: 50 mg

Dosage
?Tablets, IV Use in renal homotransplantation.
Adults and children, initial: 3-5 mg/kg (120 mg/m 2), 1-3 days before or on the day of transplantation; maintenance: 1-3 mg/kg (45 mg/m 2) daily.
Rheumatoid arthritis, SLE.
Adults and children, tablets, initial: 1 mg/kg (50-100 mg); then, increase dose by 0.5 mg/kg/day after 6-8 weeks and thereafter q 4 weeks, up to maximum of 2.5 mg/kg/day; maintenance: lowest effective dose. Dosage should be reduced in clients with renal dysfunction.
Myasthenia gravis.
2-3 mg/kg/day. However, side effects occur in more than 35% of clients.
To control progression of Behçet's syndrome.
2.5 mg/kg/day.
To treat Crohn's disease.
75-100 mg/day.

Azathioprine Ratings

Overall Rating:

2.5**~

 

(based on 2 reviews)

Effectiveness:

*~

Ease of Use:

**

Overall Satisfaction:

***~

Reviewit

Reviews

Azathioprine
2.0

Effectiveness: **

Ease of Use: *

Overall Satisfaction: ***

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Lettice, Lettice - 02/28/2014

Quotes Chimp may manage the problem of the buying price of policy contract in greater depth through the entire website.

Azathioprine
2.5

Effectiveness: *

Ease of Use: ***

Overall Satisfaction: ****

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Mariem, Mariem - 01/15/2014

Hi ChrissyIt’s so nice to hear from people who read my blog. I try to make it a fun read, but also show how Crohn’s and the suunnrodirg medication affect my life. The doctors don’t explain this kind of stuff and each person is so different; so I guess they couldn’t even if they wanted to.Im so sorry you have had a rough year, but it will get easier, the more you learn about your body and illness.My best advice about medication is not to read too much on the internet. If you read about paracetamol you will be scared, so the stronger drugs will be even worse to read about. MCAP is a strong drug and does affect your immune system. I have noticed since being on all the different meds that I get colds a bit more often but nothing worse than a weeks worth of coughing and nose running. So try not to worry about mixing with other people too much. If you do find yourself worrying then take some hand sanitiser gel and every now and again wash your hands with it. A good habit to break is putting your hands near your face. This is the way most colds get us. Try not to develop OCD though else you’ll be worse off!Stress and meeting people is what Uni is all about. Try to live as normal as possible (I know this is a silly comment as we are no longer “normal”). Make sure all of your friends are aware of your condition. I found my friends to be really interested in what’s going on with my bowel. Also might be worth having a word with your course leader. If they are aware you have a medical condition, you might be able to get longer on reports etc (could be useful if you get too busy and stressed).I think we are all stubborn with our Crohn’s. None of us want it to stop us from living our lives. Most of us succeed in putting the pains to the depths of our minds and visiting the loo every hour becomes normal. This is our life and we soon forget what it was like not to be feeling these things.MCAP had rough side effects for 3 or 4 weeks then they died down. Unfortunately for me the “good” effects have stopped too. We have to try all these things and hope that one day we find remission. If you are unhappy with your IBD health staff then you are entitled to a second opinion; Could be worth finding another specialist and talking it through with them. If you have IBD nurses available, make sure you use them. I am always on the phone to mine asking whether a side effect is normal or if I am allowed to do certain things.Make sure you sign up NACC and attend a local meeting. They are really helpful. The older guys there can give advice and the younger guys are in a similar situation. It’s the only place where you can talk openly about your illness and have the recipient know exactly what you mean. I have never talked about so much poo with strangers than when I attended my first meeting. I call it Crohn’s Anonymous.Just out of interest would you like to write a story for my blog? It might help get some things off your chest. I enjoy writing them down, plus you can get other people to read it like your friends and parents. It can be easier doing this in written form rather than verbally face-to-face. Don’t worry if you don’t want to.Please keep in touchBen