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See Also: For additional information regarding aurothioglucose, see Gold Sodium Thiomalate .
Action/Kinetics: The gold content of aurothioglucose is 50%. Time to peak effect: 4-6 hr. Mean steady-state plasma levels: 1-6 mc/mL. Is 95%-99% protein bound. t 1/2, after 11th dose: Up to 168 days. Seventy percent is excreted in the urine and 30% is excreted through the urine.
Side Effects: GI: N&V, anorexia, abdominal cramps, metallic taste, gastritis, ulcerative enterocolitis colitis. Dermatologic: Dermatitis (papular, vesicular, exfoliative), rash, urticaria, angioedema, chrysiasis. Renal: Nephrotic syndrome, glomerulonephritis with proteinuria and hematuria, acute renal failure secondary to acute tubular necrosis, acute nephritis, degeneration of proximal tubular epithelium. Hematologic: Granulocytopenia, panmyelopathy, hemorrhagic diathesis. Respiratory: Inflammation of upper respiratory tract, pharyngitis, tracheitis, bold bronchitis, interstitial pneumonitis, fibrosis. CNS: Confusion, hallucinations, seizures. Mucous membranes: Stomatitis, diffuse glossitis, gingivitis. Reactions of the nitroid type: Anaphylactoid symptoms, flushing, fainting, dizziness, sweating, N&V, malaise, headache, weakness. Ophthalmologic: Iritis, corneal ulcers, gold deposits in ocular tissues. Miscellaneous: Vaginitis.
Overdose Mangement: Treatment: Discontinue and give dimercaprol. Provide supportive therapy for renal and hematologic symptoms. In acute overdose, induce emesis or gastric lavage immediately.
How Supplied: Injection: 50 mg/mL