Aurothioglucose Suspension

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Aurothioglucose (Solganol)
(or-oh-thigh-oh- GLOO-kohz)
Pregnancy Category: C Solganol (Rx)

Classification: Antiarthritic

See Also: For additional information regarding aurothioglucose, see Gold Sodium Thiomalate .

Action/Kinetics: The gold content of aurothioglucose is 50%. Time to peak effect: 4-6 hr. Mean steady-state plasma levels: 1-6 mc/mL. Is 95%-99% protein bound. t 1/2, after 11th dose: Up to 168 days. Seventy percent is excreted in the urine and 30% is excreted through the urine.

Side Effects: GI: N&V, anorexia, abdominal cramps, metallic taste, gastritis, ulcerative enterocolitis colitis. Dermatologic: Dermatitis (papular, vesicular, exfoliative), rash, urticaria, angioedema, chrysiasis. Renal: Nephrotic syndrome, glomerulonephritis with proteinuria and hematuria, acute renal failure secondary to acute tubular necrosis, acute nephritis, degeneration of proximal tubular epithelium. Hematologic: Granulocytopenia, panmyelopathy, hemorrhagic diathesis. Respiratory: Inflammation of upper respiratory tract, pharyngitis, tracheitis, bold bronchitis, interstitial pneumonitis, fibrosis. CNS: Confusion, hallucinations, seizures. Mucous membranes: Stomatitis, diffuse glossitis, gingivitis. Reactions of the nitroid type: Anaphylactoid symptoms, flushing, fainting, dizziness, sweating, N&V, malaise, headache, weakness. Ophthalmologic: Iritis, corneal ulcers, gold deposits in ocular tissues. Miscellaneous: Vaginitis.

Overdose Mangement: Treatment: Discontinue and give dimercaprol. Provide supportive therapy for renal and hematologic symptoms. In acute overdose, induce emesis or gastric lavage immediately.

How Supplied: Injection: 50 mg/mL

•IM Only Rheumatoid arthritis.
Adults: W eek 1: 10 mg; weeks 2 and 3: 25 mg; then, 25-50 (maximum) mg/week until a total of 0.8-1 g has been administered. If client tolerates the dose and has improved, 50 mg may be given q 3-4 weeks for several months. Pediatric, 6-12 years: W eek 1: 2.5 mg; weeks 2 and 3: 6.25 mg; then, 12.5 mg/week until a total dose of 200-250 mg has been administered. Maintenance: 6.25-12.5 mg q 3-4 weeks.

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