Questions | Reviews
What is the consensus among the eye doctors about using diluted (0.1%) atropine sulfate to delay or even correct for early stage of nearsightedness? I have heard very divided opinions.
by William Teng in Tri-Cities, TN, 08/18/2006
I have a 49 year old patient that was given atropine drops for chemical trauma to the left eye by his gp. The patient stated he put one drop in 7 days ago and the pupil is mid-dilated still with pupil response and intraocular pressure of 16mmHg in bot...
by Debra K, 01/25/2006
Classification: Cholinergic blocking agent
See Also: See also Cholinergic Blocking Agents.
Action/Kinetics: Atropine blocks the action of acetylcholine on postganglionic cholinergic receptors in smooth muscle, cardiac muscle, exocrine glands, urinary bladder, and the AV and SA nodes in the heart. Ophthalmologically, atropine blocks the effect of acetylcholine on the sphincter muscle of the iris and the accommodative muscle of the ciliary body. This results in dilation of the pupil (mydriasis) and paralysis of the muscles required to accommodate for close vision (cycloplegia). Peak effect: M ydriasis 30-40 min; cycloplegia 1-3 hr. Recovery: Up to 12 days. Duration, PO: 4-6 hr. t 1/2: 2.5 hr. Metabolized by the liver although 30%-50% is excreted through the kidneys unchanged.
PO: Adjunct in peptic ulcer treatment. Irritable bowel syndrome. Adjunct in treatment of spastic disorders of the biliary tract. Urologic disorders, urinary incontinence. During anesthesia to control salivation and bronchial secretions. Has been used for parkinsonism but more effective drugs are available.
Ophthalmologic: Cycloplegic refraction or pupillary dilation in acute inflammatory conditions of the iris and uveal tract. Investigational: Treatment and prophylaxis of posterior synechiae; pre- and postoperative mydriasis; treatment of malignant glaucoma.
Additional Contraindications: Ophthalmic use: Infants less than 3 months of age, primary glaucoma or a tendency toward glaucoma, adhesions between the iris and the lens, geriatric clients and others where undiagnosed glaucoma or excessive pressure in the eye may be present, in children who have had a previous severe systemic reaction to atropine.
Special Concerns: Use with caution in infants, small children, geriatric clients, diabetes, hypo- or hyperthyroidism, narrow anterior chamber angle, individuals with Down syndrome.
Additional Side Effects: Ophthalmologic: Blurred vision, stinging, increased intraocular pressure, contact dermatitis. Long-term use may cause irritation, photophobia, eczematoid dermatitis, conjunctivitis, hyperemia, or edema.
Overdose Management: Treatment of Ocular Overdose: Eyes should be flushed with water or normal saline. A topical miotic may be necessary.
How Supplied: Injection: 0.05 mg/mL, 0.1 mg/mL, 0.4 mg/mL, 0.5 mg/mL, 0.8 mg/mL, 1 mg/mL; Ophthalmic Ointment: 1%; Ophthalmic Solution: 0.5%, 1%; Tablet: 0.4 mg