Astemizole


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Astemizole
Astemizole (Hismanil)
Astemizole
(ah- STEM-ih-zohl)
Pregnancy Category: C Hismanil (Rx)

Classification: Antihistamine, miscellaneous

See Also: See also Antihistamines .

Action/Kinetics: Low to no sedative, antiemetic, or anticholinergic effects. Absorption decreased up to 60% when taken with food. Metabolized in the liver to both active and inactive metabolites and excreted through the feces. t 1/2: About 1.6 days. Onset: 2-3 days. Duration: Up to several weeks. Over 95% is bound to plasma protein. Mainly excreted through the feces.

Uses: Allergic rhinitis, urticaria.

Contraindications: Impaired hepatic function. Concomitant use with erythromycin, clarithromycin, itraconazole, ketoconazole, mibefradil, quinine, and troleandomycin.

Special Concerns: Dose should not exceed 10 mg/day.

Additional Side Effects Serious CV side effects, including death, cardiac arrest, QT interval prolongation, torsades de pointes and other ventricular arrhythmias have been observed in clients exceeding the recommended dose of astemizole. Severe hepatic impairment. Syncope may precede severe arrhythmias. Overdose may be observed with doses as low as 20-30 mg/day.

Drug Interactions: Clarithromycin / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Erythromycin / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Itraconazole / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Ketoconazole / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Miconazole / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Mibefradil / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir) / Inhibition of metabolism of astemizole Quinine / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Serotonin reuptake inhibitors (fluoxetine, fluvoxamine, nefazodone, paroxetin, sertraline) / Inhibition of metabolism of astemizole Troleandomycin / Possible serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Zileuton / Inhibition of metabolism of astemizole

How Supplied: Tablet: 10 mg

Dosage
•Tablets
Adults and children over 12 years: 10 mg once daily. Children, 6-12 years: 5 mg daily; children, less than 6 years: 0.2 mg/kg/day.

Astemizole Ratings

Overall Rating:

3.0***

 

(based on 3 reviews)

Effectiveness:

***

Ease of Use:

***

Overall Satisfaction:

***

Reviewit

Reviews

Astemizole
3.0

Effectiveness: ***

Ease of Use: ***

Overall Satisfaction: ***

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Astemizole
3.0

Effectiveness: *

Ease of Use: ****

Overall Satisfaction: ****

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Dew, Dew - 02/06/2014

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Astemizole
3.0

Effectiveness: *****

Ease of Use: **

Overall Satisfaction: **

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Sonia, Sonia - 01/10/2014

on all acounts. Sounds like we're both cut from the same mold as far as golf eqepumint needs and etiqutte. I'm currently playing a set of Callaway irons, but have set up a club fitting for next month for a new set of the Titleist AP2 712 irons. I agree on the overuse of logos on eqepumint and apparrel. For me, the more plain, classic looking, the better.Happy playing, and go low.Scott Stephenson