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Classification: Antihistamine, miscellaneous
See Also: See also Antihistamines .
Action/Kinetics: Low to no sedative, antiemetic, or anticholinergic effects. Absorption decreased up to 60% when taken with food. Metabolized in the liver to both active and inactive metabolites and excreted through the feces. t 1/2: About 1.6 days. Onset: 2-3 days. Duration: Up to several weeks. Over 95% is bound to plasma protein. Mainly excreted through the feces.
Uses: Allergic rhinitis, urticaria.
Contraindications: Impaired hepatic function. Concomitant use with erythromycin, clarithromycin, itraconazole, ketoconazole, mibefradil, quinine, and troleandomycin.
Special Concerns: Dose should not exceed 10 mg/day.
Additional Side Effects Serious CV side effects, including death, cardiac arrest, QT interval prolongation, torsades de pointes and other ventricular arrhythmias have been observed in clients exceeding the recommended dose of astemizole. Severe hepatic impairment. Syncope may precede severe arrhythmias. Overdose may be observed with doses as low as 20-30 mg/day.
How Supplied: Tablet: 10 mg