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Classification: Anticoagulant, low molecular weight heparin
See Also: See also Heparins, Low Molecular Weight.
Action/Kinetics: Plasma levels of ardeparin can not be measured directly; rather, serine protease activity is used. Well absorbed following SC administration. t 1/2, disposition: 3.3 hr (for ardeparin anti-Xa) and 1.2 hr (for ardeparin anti-IIa).
Uses: Prophylaxis of deep vein thrombosis following knee replacement surgery. Investigational: Secondary prophylaxis for recurrent thromboembolic events.
Additional Contraindications: Hypersensitivity to propylparaben.
Special Concerns: See also Heparins, Low Molecular Weight. The product contains metabisulfite that may cause allergic reactions in susceptible persons.
Side Effects: Bleeding events: Intraoperative bleeding, postoperative surgical site or nonsurgical site hematoma or hemorrhage, bleeding requiring an invasive procedure; ecchymosis, GI hemorrhage hematemesis, hematuria, melena, petechiae, rectal hemorrhage, retroperitoneal hemorrhage, CVA abnormal stools. GI: N&V, constipation. Allergic reaction: Maculopapular rash, vesiculobullous rash, urticaria. CNS: Confusion, dizziness, headache, insomnia. Miscellaneous: Fever, pruritus, anemia, thrombocytopenia, arthralgia, chest pain, dyspnea, reactions at injection site (edema, hypersensitivity, inflammation, pain), peripheral edema.
How Supplied: Injection: 5,000 U/0.5 mL; 10,000 U/0.5 mL