Antithrombin III (Human)


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Antithrombin III (Human)
Antithrombin III (Human) (Thrombate III)
Antithrombin III
(an-tee- THROM-bin)
Pregnancy Category: B Thrombate III (Rx)

Classification: Antithrombin

Action/Kinetics: Antithrombin III (AT-III) is the major plasma inhibitor of thrombin. For therapeutic use it is obtained from plasma of human volunteers. Inactivation of thrombin by AT-III results from formation of a covalent bond causing an inactive 1:1 stoichiometric complex between thrombin and AT-III. AT-III also inactivates other components of the coagulation cascade including factors IXa, Xa, XIa, and XIIa, and plasmin. t 1/2: 2.5 days (based on immunologic assays).

Uses: Hereditary AT-III deficiency in pregnant clients, in clients requiring surgery, and in individuals with thromboembolism.

Special Concerns: Safety and effectiveness have not been determined in children. Even though special precautions are taken to screen plasma donors, clients may develop S&S of viral infections, especially hepatitis C.

Side Effects: GI: Nausea, foul taste in mouth, bowel fullness. CNS: Dizzness, lightheadedness. Respiratory: Chest tightness, shortness of breath, chest pain. Miscellaneous: Chills, cramps, film over eye, hives, fever, oozing, hematoma.

Drug Interactions: The anticoagulant effect of heparin is increased when used concomitantly with AT-III; decrease the dose of heparin during AT-III therapy.

How Supplied: Powder for injection, lyophilized: 500 IU, 1000 IU

Dosage
?IV only
Individualize dose depending on the pretherapy plasma AT-III level. The dosage can be calculated from the following formula:  units required (IU) = [desired AT-III level (%) - baseline AT-III level (%)]/1.4 x body weight (kg).  The formula is based on an expected incremental recovery above baseline levels for AT-III of 1.4%/IU/kg given. Each bottle of AT-III has the functional activity, in international units (IU) stated on the label.


The following regimen may be used as a starting point for treatment; modification is based on actual plasma AT-III levels reached.

    1. Calculate the initial loading dose to elevate plasma AT-III levels to 120%, assuming a rise over baseline plasma AT-III of 1.4% (functional activity)/IU/kg given.

    2. Measure plasma AT-III levels preinfusion, 20 minutes postinfusion (peak), after 12 hr, and preceding the next infusion (trough level). Subsequently, measure AT-III levels preceding and 20 min after each infusion until predictable peak and trough levels have been reached (usually between 80% and 120%). Plasma levels between 80% and 120% may be maintained by giving maintenance doses of 60% of the initial loading dose q 24 hr. Adjust the maintenance dose or interval between doses based on actual plasma AT-III levels reached.


If AT-III therapy is indicated for a client with hereditary deficiency to control an acute thrombotic episode or to prevent thrombosis following surgical or obstetrical procedures, increase the AT-III plasma level to normal and maintain for 2-8 days. This will depend on the reason for treatment, type and extensiveness of surgery, medical condition and history of the client, and judgment of the physician.

Antithrombin III (Human) Ratings

Overall Rating:

2.5**~

 

(based on 2 reviews)

Effectiveness:

**~

Ease of Use:

***

Overall Satisfaction:

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Reviews

Antithrombin III (Human)
3.0

Effectiveness: ***

Ease of Use: *****

Overall Satisfaction: *

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Bayle, Bayle - 03/06/2014

Succumbing to the soothing but meaningless slogans created by Madison Avenue may be easy, but if QuotesChimp buy our insurance based on name recognition alone, we allow insurance companies to slip off the hook of having to truly compete for our business by offering better prices and better services. We can think of few more beneficial consumer skills you can develop than to become a wise and competent shopper of insurance products. The more you know about what you are being sold, the more you will be able to keep your own dollars in your own pockets while obtaining a better deal for a better product.

Antithrombin III (Human)
1.5

Effectiveness: **

Ease of Use: *

Overall Satisfaction: **

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Arbin, Arbin - 01/14/2014

Kris, on my website I list a few sites where I get some info. The poebrlm with these sites is that they really take goat keeping to another level. Had I read these sites before getting goats, I probably would have stuck with chickens! Goats are very easy keepers and I find that if you feed them good food, you'll rarely have poebrlms. Most people don't give their goats grain I do just a little it keeps their coat shiny but most important for me is that it keeps them FRIENDLY! I use the simplest methods and what works for me. As for clearing brush, you'd do fine with inexpensive brush goats Make sure to worm them quarterly and protect them from rain and coyotes and stray dogs and they'll be happy to work for you! If you don't want babies, then don't get a billy! And don't give these guys hay if you don't have to. You'll spoil them and they won't want to eat your brush!Check craigslist in your area you may find some good deals on goats!