Ampicillin sodium/Sulbactam sodium

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Ampicillin sodium/Sulbactam sodium
Ampicillin sodium/ Sulbactam sodium (Unasyn)
Ampicillin sodium/Sulbactam sodium
(am-pih- SILL-in/sull- BACK-tam)
Pregnancy Category: B Unasyn (Rx)

Classification: Antibiotic, penicillin

See Also: See also Anti-Infectives and Penicillins.

Content: The Powder for Injection contains either 1 g ampicillin sodium and 0.5 g sulbactam sodium, 2 g ampicillin sodium and 1 g sulbactam sodium, or 10 g ampicillin and 5 g sulbactam sodium.

Action/Kinetics: For details, see Ampicillin oral. Sulbactam is present in this product because it irreversibly inhibits beta-lactamases, thus ensuring activity of ampicillin against beta-lactamase-producing microorganisms. Thus, sulbactam broadens the antibiotic spectrum of ampicillin to those bacteria normally resistant to it. Peak serum levels, after IV infusion: 15 min. t 1/2, both drugs: about 1 hr. From 75%-85% of both drugs is excreted unchanged in the urine within 8 hr after administration.

Uses: Infections caused by beta-lactamase-producing strains of the following: (a) skin and skin structure infections caused by Staphylococcus aureus, Escherichia coli, Klebsiella species (including K. pneumoniae), Proteus mirabilis, Bacteroides fragilis, Enterobacter species, and Acinetobacter calcoaceticus; (b) intra-abdominal infections caused by E. coli, Klebsiella species (including K. pneumoniae), Bacteroides (including B. fragilis and Enterobacter) (c) gynecologic infections caused by E. coli and Bacteroides (including B. fragilis). NOTE: Mixed infections caused by ampicillin-susceptible organisms and beta-lactamase-producing organisms are susceptible to this product; thus, additional antibiotics do not have to be used.

Special Concerns: Safety and efficacy in children 1 year of age and older have not been established for intra-abdominal infections or for IM administration.

Side Effects: At site of injection: Pain and thrombophlebitis. GI: Diarrhea, N&V, flatulence, abdominal distention, glossitis. CNS: Fatigue, malaise, headache. GU: Dysuria, urinary retention. Miscellaneous: Itching, chest pain, edema, facial swelling, erythema, chills, tightness in throat, epistaxis, substernal pain, mucosal bleeding, candidiasis.

Laboratory Test Alterations: AST, ALT, alkaline phosphatase, LDH, creatinine, BUN; also, basophils, eosinophils, lymphocytes, monocytes, platelets. Serum albumin and total proteins, H&H, RBCs, WBCs, and platelets. Presence of RBCs and hyaline casts in urine.

Overdose Management: Symptoms: Neurologic symptoms, including convulsions. Treatment: Both ampicillin and sulbactam may be removed by hemodialysis.

How Supplied: See Content

Adults: 1 g ampicillin/0.5 g sulbactam to 2 g ampicillin/1 g sulbactam q 6 hr, not to exceed 4 g sulbactam daily. Doses must be decreased in renal impairment. Children, over 40 kg: Use adult doses; total sulbactam dose should not exceed 4 g/day. Children, one year and older but less than 40 kg: 200 mg ampicillin/kg/day and 100 mg sulbactam/kg/day in divided doses q 6 hr.

Ampicillin sodium/Sulbactam sodium Ratings

Overall Rating:



(based on 3 reviews)



Ease of Use:


Overall Satisfaction:




Ampicillin sodium/Sulbactam sodium

Effectiveness: ****

Ease of Use: **

Overall Satisfaction: ***


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Ampicillin sodium/Sulbactam sodium

Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****


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Ampicillin sodium/Sulbactam sodium

Effectiveness: ***

Ease of Use: *****

Overall Satisfaction: *


Giovanna, Giovanna - 01/10/2014

This is not surprising to me at all. I awlays tell clients Don't believe ANYTHING on the front of a package. Instead, you must turn the product around and read the ingredients. To make food kid friendly , manufacturers add more sugar, artificial sweeteners and harmful additives and colors to make it more appealing (and addictive!). Sadly, most of these foods already have high sugar and sodium contents to start with!