Amoxapine


Questions | Reviews ***

We don't currently have any questions about Amoxapine.

Amoxapine
Amoxapine (Asendin)
Amoxapine
(ah- MOX-ah-peen)
Pregnancy Category: C Asendin (Rx)

Classification: Antidepressant, tricyclic

See Also: See also Antidepressants, Tricyclic.

Action/Kinetics: In addition to its effect on monoamines, this drug also blocks dopamine receptors. Significant anticholinergic effects, moderate sedation, and slight orthostatic hypotensive effect. Metabolized to the active metabolites 7-hydroxy- and 8-hydroxyamoxapine. Peak blood levels: 90 min. Effective plasma levels: 200-500 ng/mL. Time to reach steady state: 2-7 days. t 1/2: 8 hr; t 1/2 of major metabolite: 30 hr. Excreted in urine.

Uses: Endogenous and psychotic, as well as neurotic or reactive depressions. Depression accompanied by anxiety or agitation.

Contraindications: Avoid high dose levels in clients with a history of convulsive seizures. During acute recovery period after MI. Use in children less than 16 years of age.

Special Concerns: Safe use in children under 16 years of age and during lactation not established.

Additional Side Effects: Tardive dyskinesia. Overdosage may cause seizures (common), neuroleptic malignant syndrome testicular swelling, impairment of sexual function, and breast enlargement in males and females. Also, renal failure may be seen 2-5 days after overdosage.

How Supplied: Tablet: 25 mg, 50 mg, 100 mg, 150 mg

Dosage
?Tablets Antidepressant.
Adults, individualized, initial: 50 mg b.i.d.-t.i.d. Can be increased to 100 mg b.i.d.-t.i.d. during first week. Due to sedation, do not use doses greater than 300 mg/day unless this dose has been ineffective for at least 14 days. Maintenance: 300 mg as a single dose at bedtime. Hospitalized clients: Up to 150 mg q.i.d. Geriatric, initial: 25 mg b.i.d.-t.i.d. If necessary and tolerated, increase to 50 mg b.i.d.-t.i.d. after first week. Maintenance: Up to 300 mg/day at bedtime.

Amoxapine Ratings

Overall Rating:

3.0***

 

(based on 2 reviews)

Effectiveness:

***

Ease of Use:

*****

Overall Satisfaction:

*

Reviewit

Reviews

Amoxapine
3.5

Effectiveness: ****

Ease of Use: *****

Overall Satisfaction: *

Avatar_thumbnail

Krystal, Krystal - 02/28/2014

The responsibility to comply with the specific conditions outlined in your QuotesChimp, including paying premiums on time, cooperating with insurance com�panies when they defend your claims, and reporting changes that may affect your coverage.

Amoxapine
2.5

Effectiveness: **

Ease of Use: *****

Overall Satisfaction: *

Avatar_thumbnail

Esam, Esam - 01/14/2014

Now that's sutleb! Great to hear from you.