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I WAS PRESCRIBED AMITRIPTYLINE IN 2006. I AM UNABLE TO READ THE DOSAGE OF WHICH I WAS GIVEN, WHEN I WENT TO A NEW DOCTOR, AND TOLD HIM THAT I WAS ON THIS, I THOUGHT IT HAD SAID 10MG'S BUT WHEN I WENT TO THE PHARMACY I HAD ASKED THEM TO LOOK ...
by JESSIE in US, 07/08/2007
is there any pk/pd relationship for amitriptyline. how does an sustained release formulation of amitriptyline work. is there sedation side effect for low dose of 25 mg.
by smita in uk, 07/19/2006
Classification: Antidepressant, tricyclic
See Also: See also Antidepressants, Tricyclic.
Action/Kinetics: Amitriptyline is metabolized to an active metabolite, nortriptyline. Has significant anticholinergic and sedative effects with moderate orthostatic hypotension. Very high ability to block serotonin uptake and moderate activity with respect to norepinephrine uptake. Effective plasma levels of amitriptyline and nortriptyline: Approximately 110-250 ng/mL. Time to reach steady state: 4-10 days. t 1/2: 31-46 hr. Up to 1 month may be required for beneficial effects to be manifested.
Uses: Relief of symptoms of depression, including depression accompanied by anxiety and insomnia. Chronic pain due to cancer or other pain syndromes. Prophylaxis of cluster and migraine headaches. Investigational: Pathologic laughing and crying secondary to forebrain disease, bulimia nervosa, antiulcer agent, enuresis. Adjunct analgesic for phantom limb pain, migraine, chronic tension headaches, diabetic neuropathy, tic douloureux, cancer pain, peripheral neuropathy with pain, postherpetic neuralgia, arthritic pain. Dermatologic disorders (chronic urticaria and angioedema, nocturnal pruritus in atopic eczema).
Contraindications: Use in children less than 12 years of age.
Additional Drug Interactions: May block the antihypertensive effect of guanethidine and similar drugs.
How Supplied: Injection: 10 mg/mL; Tablet: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg