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Classification: Beta-adrenergic blocking agent
See Also: See also Beta-Adrenergic Blocking Agents.
Action/Kinetics: Predominantly beta-1 blocking activity but will inhibit beta-2 receptors at higher doses. Some intrinsic sympathomimetic activity. t 1/2: 3-4 hr. Low lipid solubility. Duration: 24-30 hr. Metabolized in liver and excreted in urine and bile. Fifteen to 20% excreted unchanged.
Uses: Hypertension (either alone or with other antihypertensive agents such as thiazide diuretics). Premature ventricular contractions.
Additional Contraindications: Severe, persistent bradycardia.
Special Concerns: Dosage not established in children.
How Supplied: Capsule: 200 mg, 400 mg