Acebutolol hydrochloride
Acebutolol hydrochloride (Rhotral& Sectral)
Acebutolol hydrochloride
(ays- BYOU-toe-lohl)
Pregnancy Category: B Apo-Acebutolol Monitan Novo-Acebutolol Nu-Acebutolol Rhotral Sectral (Rx)

Classification: Beta-adrenergic blocking agent

See Also: See also Beta-Adrenergic Blocking Agents.

Action/Kinetics: Predominantly beta-1 blocking activity but will inhibit beta-2 receptors at higher doses. Some intrinsic sympathomimetic activity. t 1/2: 3-4 hr. Low lipid solubility. Duration: 24-30 hr. Metabolized in liver and excreted in urine and bile. Fifteen to 20% excreted unchanged.

Uses: Hypertension (either alone or with other antihypertensive agents such as thiazide diuretics). Premature ventricular contractions.

Additional Contraindications: Severe, persistent bradycardia.

Special Concerns: Dosage not established in children.

Drug Interactions: Aloe / Acebutolol effect Buckthorn / Acebutolol effect Cascara sagrada bark / Acebutolol effect Ephedra / Dysrhythmia Rhubarb root / Acebutolol effect Senna / Acebutolol effect

How Supplied: Capsule: 200 mg, 400 mg

Dosage
?Capsules Hypertension.
Initial: 400 mg/day (although 200 mg b.i.d. may be needed for optimum control); then, 400-800 mg/day (range: 200-1,200 mg/day).
Premature ventricular contractions.
Initial: 200 mg b.i.d.; then, increase dose gradually to reach 600-1,200 mg/day.
Dosage should not exceed 800 mg/day in geriatric clients. In those with impaired kidney or liver function, decrease dose by 50% when C _CR is 50 mL/min/1.73 m ² and by 75% when it is less than 25 mL/min/1.73 m ².