Zosyn (Injection)

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Zosyn (Injection) Drug and Prescription Information

Zosyn (Injection)

Zosyn (Injection) Medication Classification


Zosyn (Injection) Brandname


Zosyn (Injection) is used for the Treatment

Piperacillin (pi-PER-a-sil-in), Tazobactam (ta-zoe-BAK-tam) Treats infections. Belongs to a class of drugs called penicillin antibiotics.

When To Not Use Zosyn (Injection)

You should not use this medicine if you have ever had an allergic reaction to piperacillin or any penicillin medicine.

How Should You Use Zosyn (Injection)


  • Your doctor will prescribe your exact dose and tell you how often it should be given.
  • An IM injection is a shot given in your muscle (upper arm, thigh, buttocks). An IV infusion is medicine that is put directly into your body through one of your veins.
  • This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
  • If you are receiving IV medicine, check the bag to make sure there are no leaks. Also make sure the solution is clear.
  • If a dose is missed:
  • This medicine needs to be given on a regular schedule. Take the missed dose as soon as you remember, and take the rest of the doses for the day at regularly spaced time intervals.
  • If you miss more than one dose, call your doctor for instructions.

Proper Zosyn (Injection) Storage

Store Zosyn (Injection) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Zosyn (Injection) and all medications out of the reach of children.

What To Avoid While Using Zosyn (Injection)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking probenecid before you take this medicine.
  • Birth control pills may not work as well while taking piperacillin/tazobactam. Use another kind of birth control while you are taking this medicine.

Zosyn (Injection) Warnings

  • Make sure your doctor knows if you have ever had an allergic reaction to any cephalosporin antibiotic such as Keflex® or Ceclor® before you take piperacillin/tazobactam.
  • Make sure your doctor knows if you have mononucleosis (mono), stomach or intestinal disease, asthma, liver disease, hay fever, or other allergies before you take this medicine.
  • If your infection does not improve, or if it gets worse while taking this medicine, talk to your doctor.
  • If you have severe diarrhea while taking piperacillin/tazobactam, check with your doctor before taking medicine to stop the diarrhea.
  • If you are pregnant or breastfeeding, talk to your doctor before taking piperacillin/tazobactam.

Zosyn (Injection) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Rash or hives
  • Blistering or peeling skin
  • Swelling of the face, throat, or lips
  • Wheezing or trouble breathing
  • Severe diarrhea (watery or bloody)
  • Swelling, pain, or redness near where your IV is located
  • If you notice these less serious side effects, talk with your doctor:
  • Mild diarrhea or nausea
  • Sore mouth or tongue
  • Vaginal itching or discharge
  • Pain where your IM shot was given

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