TRANYLCYPROMINE (Oral) (Tablet)


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TRANYLCYPROMINE (Oral) (Tablet) Drug and Prescription Information

TRANYLCYPROMINE (Oral) (Tablet)

TRANYLCYPROMINE (Oral) (Tablet) Medication Classification

TRANYLCYPROMINE (By mouth)

TRANYLCYPROMINE (Oral) (Tablet) Brandname

Parnate

TRANYLCYPROMINE (Oral) (Tablet) is used for the Treatment

Tranylcypromine (tran-il-SIP-roe-meen) Treats depression. This medicine is a monoamine oxidase (MAO) inhibitor.

When To Not Use TRANYLCYPROMINE (Oral) (Tablet)

You should not use this medicine if you have had an allergic reaction to tranylcypromine. Do not use this medicine if you have high blood pressure, liver disease, heart disease, or severe kidney disease. Do not use this medicine if you have severe or frequent headaches, or pheochromocytoma (a tumor of the adrenal gland). You should not use this medicine if you have ever had a stroke, transient ischemic attack (TIA), or any other kind of cerebrovascular disease. There are many medicines that you should not use while you are using tranylcypromine. This includes medicine you can buy without a prescription (over-the counter). Make sure your doctor knows about all other medicines you are using. You may need to wait at least 14 days between using an MAO inhibitor and any other medicine. You must wait at least 5 weeks after you stop using Prozac® before you can start using tranylcypromine.

How Should You Use TRANYLCYPROMINE (Oral) (Tablet)

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • You may need to use this medicine for as long as 4 weeks before you start feeling better.
  • If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

Proper TRANYLCYPROMINE (Oral) (Tablet) Storage

Store TRANYLCYPROMINE (Oral) (Tablet) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep TRANYLCYPROMINE (Oral) (Tablet) and all medications out of the reach of children.

What To Avoid While Using TRANYLCYPROMINE (Oral) (Tablet)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows about all other medicines you are using. MAO inhibitors can be very dangerous if used with certain other medicines. You may need to wait at least 14 days between using an MAO inhibitor and using another medicine. Wait 5 weeks if you are changing from Prozac® to Marplan®.
  • Do not drink alcohol while you are using this medicine. This includes Chianti wine, sherry, beer, non-alcohol or low alcohol beer and wine, and liqueurs. Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Certain foods and drinks can cause dangerously high blood pressure in people who are using an MAO inhibitor. This is more common with aged, smoked, or fermented foods that are high in tyramine. Some foods you should not eat are cheese (especially strong or aged kinds), caviar, sour cream, liver, canned figs, soy sauce, sauerkraut, fava beans, yeasts, and yogurt. Avoid smoked or pickled meat, poultry, or fish, such as sausage, pepperoni, salami, anchovies, or herring. Do not eat dried fruit (such as raisins), bananas, avocados, raspberries, or very ripe fruit.
  • Do not drink or eat too much caffeine while you are using this medicine. Caffeine can be found in coffee, cola, chocolate, tea, and other foods and drinks. Ask your doctor how much caffeine is safe.

TRANYLCYPROMINE (Oral) (Tablet) Warnings

  • Make sure your doctor knows if you are pregnant or breast feeding. Tell your doctor if you have Parkinson's disease, angina (chest pain), kidney disease, diabetes, or epilepsy. Your doctor also needs to know if you have schizophrenia, bipolar (manic-depressive) disorder, overactive thyroid, or a history of drug or alcohol addiction.
  • Your blood pressure might get too high while you are using this medicine. This may cause headaches, blurred vision, and other symptoms. You might need to keep track of your blood pressure between doctor appointments. If you think your blood pressure is getting too high, call your doctor right away.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • This medicine may make you dizzy, drowsy, faint, or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

TRANYLCYPROMINE (Oral) (Tablet) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Bright light bothering your eyes more than normal.
  • Unusual sweating, sometimes with fever or cold skin.
  • Fast, slow, or pounding heartbeat.
  • Feeling nervous, restless, anxious, agitated, or excited for no reason.
  • Headache, especially in the back of your head.
  • Seeing or hearing things that are not there, or severe confusion.
  • Stiff or sore neck.
  • Tightness in your throat or chest.
  • Vomiting and nausea.
  • If you notice these less serious side effects, talk with your doctor:
  • Dry mouth
  • Nausea, diarrhea, stomach pain, constipation.

TRANYLCYPROMINE (Oral) (Tablet) Ratings

Overall Rating:

3.0***

 

(based on 2 reviews)

Effectiveness:

***

Ease of Use:

***~

Overall Satisfaction:

**~

Reviewit

Reviews

TRANYLCYPROMINE (Oral) (Tablet)
2.5

Effectiveness: **

Ease of Use: *****

Overall Satisfaction: *

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Jorge, Jorge - 01/13/2014

The one situation in which MAOi drugs are codnsiered the "big guns" is treatment-resistant depression of the atypical subtype. You can find a number of references to "MAOIs and atypical depression" in the literature. While I can't find much evidence for why that is, I suspect it's because MAOIs have a reputation for being more activating (less anxiolytic but better for anergic depressions) than the SSRIs, save perhaps for Prozac.They are also a better choice than the TCAs (after SSRIs/SNRIs/NDRIs/NaSSAs) if there's a concern about suicide risk.I can imagine limited street potential. Tranylcypromine is definitely buzzier than phenelzine. Selegiline is used to potentiate other drugs (for the wonky psychonauts, it's used when available in place of botanical MAO inhibitors like the harmala alkaloids). All three, I think, have amphetamine or methamphetamine metabolites that can show up as a positive on a drug test.The selegiline transdermal patch was a great idea but it doesn't seem to be delivering so well (look at the studies on it, and you see an improvement in the HAM-D of only a few points over placebo). This might be because the dosages top out at 12mg patches, but I wouldn't know. I still wonder why they made an antidepressant transdermal patch out of an MAOI that is primarily used as a Parkinsons drug, though. The advantage of transdermal systems, of course, is bypassing the first-pass hepatic metabolism and mostly bypassing the gut, where those nasty tyramine interactions occur. And selegiline is not as notorious as the totally nonselective antidepressant MAOIs for tyramine reactions. So you'd imagine there ought to be some incentive to make a transdermal patch out of tranylcypromine (Parnate) or some other depression-focused MAOI.Lastly, MAOIs are generally codnsiered more powerful among the patient community. This is probably because by the time you get to an MAOI, you've had ongoing depression (and depression degenerates and becomes a self-reinforcing spiral as you fail treatments - so I would argue that severe depression is perfectly likely to be treatment-resistant, or perhaps vice versa). If you have a lifelong case of biological, recurrent depression, your chances of repeated tachyphylaxis (aka "Prozac poop-out") on the first- and second-line drugs is very high, simply because of the duration of treatment.(Happened to me...)So as each medication and class of medications either doesn't work, or eventually stops working, the MAOIs can be the "last stop" on the treatment line before ECT. If they work, then, they are codnsiered a powerful miracle.