Purinethol (Oral)

Questions | Reviews ***~

Purinethol and vomiting

My 14 year old son is on 75 mg of purinethol (6MP) and has started vomiting one night, then the following week again for one night. Now he has been vomiting for 2 1/2 days. We are keeping him hydrated by drinking fluids, which he holds for a few hours...
by Maria in Freehold, NJ, 11/26/2005

purinethol substitutions

what is the substitute of the purinethol?
by nancy in egypt_cairo, 10/30/2006

Purinethol (Oral) Drug and Prescription Information

Purinethol (Oral)

Purinethol (Oral) Medication Classification


Purinethol (Oral) Brandname


Purinethol (Oral) is used for the Treatment

Mercaptopurine (mer-kap-toe-PYOOR-een) Treats leukemia.

When To Not Use Purinethol (Oral)

You should not use this medicine if you had an allergic reaction to mercaptopurine or thioguanine, or if you have ever been treated with mercaptopurine or thioguanine (Tabloid®) and the medicines did not work. You should not use mercaptopurine if you are pregnant.

How Should You Use Purinethol (Oral)


  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
  • If a dose is missed:
  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

Proper Purinethol (Oral) Storage

Store Purinethol (Oral) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Purinethol (Oral) and all medications out of the reach of children.

What To Avoid While Using Purinethol (Oral)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using a blood thinner (Coumadin®), allopurinol (Zyloprim®), cotrimoxazole (Bactrim®), olsalazine (Dipentum®), mesalamine (Asacol®), or sulfasalazine (Azulfidine®).
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving mercaptopurine. Vaccines may not work as well while you are using this medicine.

Purinethol (Oral) Warnings

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, kidney disease, gout, or inflammatory bowel disease.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Purinethol (Oral) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Bloody or black, tarry stools
  • Dark-colored urine or pale stools
  • Nausea, vomiting, diarrhea, loss of appetite, pain in the upper stomach
  • Severe pain or swelling in your joints
  • Unexplained fever, sore throat, chills
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes
  • If you notice these less serious side effects, talk with your doctor:
  • Darkening of skin color
  • Mild diarrhea
  • Mild skin rash

Purinethol (Oral) Ratings

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