PROMETHAZINE (Injection) (Injectable)

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Promethazine Injectable

I am a pharmacist for an ambulatory surgery center.  What is the latest news on Promethazine injectable?  I am told some major hospitals in our area are disallowing the use of Promethazine IV .  It can be used IM but not IV (for all pat...
by Cindy Yelverton in Plano, Texas, 09/11/2006

PROMETHAZINE (Injection) (Injectable) Drug and Prescription Information

PROMETHAZINE (Injection) (Injectable)

PROMETHAZINE (Injection) (Injectable) Medication Classification


PROMETHAZINE (Injection) (Injectable) Brandname

Antinaus 50, Promacot, Prorex, Phenergan

PROMETHAZINE (Injection) (Injectable) is used for the Treatment

Promethazine (proe-METH-a-zeen) Treats, nausea and vomiting. Also used to treat allergic reactions.

When To Not Use PROMETHAZINE (Injection) (Injectable)

You should not use this medicine if you have had an allergic reaction to promethazine. You should not use promethazine if you are breastfeeding or if you have asthma, narrow-angle glaucoma, stomach or bladder problems, or an enlarged prostate. This medicine should not be given to children under 2 years old.

How Should You Use PROMETHAZINE (Injection) (Injectable)


  • Your doctor will prescribe your exact dose and tell you how often it should be given.
  • An IM injection is a shot given in your muscle (upper arm, thigh, buttocks).
  • An IV infusion is medicine that is put directly into your body through one of your veins.
  • This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or a friend can be taught to give your medicine.
  • If a dose is missed:
  • Use your medicine as soon as you remember that you have missed your dose.
  • Take the rest of your doses for that day at evenly spaced time intervals.
  • You should not use two doses at the same time.

Proper PROMETHAZINE (Injection) (Injectable) Storage

Store PROMETHAZINE (Injection) (Injectable) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep PROMETHAZINE (Injection) (Injectable) and all medications out of the reach of children.

What To Avoid While Using PROMETHAZINE (Injection) (Injectable)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also taking an MAO inhibitor (Marplan®, Nardil®, Parnate®, Eldepryl®), or other medicines that may make you sleepy such as cold and allergy medicine, narcotic pain-killers, sleeping pills, or tranquilizers.
  • Avoid drinking alcohol while taking promethazine.

PROMETHAZINE (Injection) (Injectable) Warnings

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Before using this medicine, tell your doctor if you have an overactive thyroid, heart or liver disease, high blood pressure, a seizure disorder (epilepsy), bone marrow disease, or diabetes.
  • Tell your doctor or dentist you are using promethazine before you have any kind of surgery.
  • This medicine may make you drowsy or dizzy. Be careful when driving or using machinery.
  • This medicine may make you more sensitive to sunlight. Use a sunscreen when outdoors. Avoid tanning beds and sunlamps.

PROMETHAZINE (Injection) (Injectable) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Fast, slow, or irregular heartbeat
  • Slow or troubled breathing
  • Skin rash, itching, hives
  • Yellowing of skin or eyes
  • Pain, burning, or swelling where the IV or shot was given
  • Blurred vision, ringing in the ears
  • If you notice these less serious side effects, talk with your doctor:
  • Drowsiness or dizziness
  • Trouble sleeping, restlessness, depression
  • Dry mouth
  • Constipation

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