Prolastin (Injection)

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Prolastin (Injection) Drug and Prescription Information

Prolastin (Injection)

Prolastin (Injection) Medication Classification


Prolastin (Injection) Brandname

Prolastin, Zemaira, Aralast

Prolastin (Injection) is used for the Treatment

Alpha-1 Proteinase Inhibitor Human (AL-fa 1 PRO-teen-aze in-HIB-i-tor HYOO-man) Treats emphysema (a lung disorder). Also called alpha-1 PI, alpha-1 antitrypsin, or AAT.

When To Not Use Prolastin (Injection)

You should not use this medicine if you have had an allergic reaction to alpha-1 proteinase inhibitor (alpha-1 PI). Patients that have too little IgA (immunoglobulin A, a part of the immune system) should not be given alpha-1 PI.

How Should You Use Prolastin (Injection)


  • The medicine is given through a tube that goes directly into a blood vein (intravenous, or IV).
  • Before you use this medicine, you should be trained to use IV equipment and know how to mix the powder in sterile water. Otherwise, your medicine should be given by your home health caregiver.
  • When it is time for your treatment, bring the medicine and sterile water to room temperature.
  • Mix the medicine and sterile water as you have been taught.
  • After you have mixed the medicine, use it within 3 hours. Do not refrigerate the medicine after it has been prepared for your treatment.
  • Before you start your treatment, look at the liquid in the bag or bottle. If you see any specks or solid pieces in the bag or bottle, you should not use it. Prepare a new dose of the medicine.
  • If a dose is missed:
  • Try not to miss a dose. If possible, have other family members trained to give your treatment in case you are unable to give it yourself.
  • If you do miss a dose, contact your doctor for instructions.

Proper Prolastin (Injection) Storage

Store Prolastin (Injection) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Prolastin (Injection) and all medications out of the reach of children.

What To Avoid While Using Prolastin (Injection)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not mix any other medicine with the alpha-1 PI solution, unless directed by your doctor.

Prolastin (Injection) Warnings

  • Check with your doctor before taking alpha-1 PI if you have heart disease or are pregnant or breastfeeding.
  • Alpha-1 PI is taken from human blood that has been tested for viruses and treated to prevent the spread of infections. The risk of getting an infection from alpha-1 PI is very low, but cannot be completely eliminated. As a precaution, you should be given a hepatitis B vaccine before receiving this medicine.
  • If there is not enough time for the vaccine to start working before your treatments begin, you may be given both a dose of hepatitis B immune globulin and a hepatitis B vaccine.

Prolastin (Injection) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Wheezing or chest tightness
  • Hives or rash
  • If you notice these less serious side effects, talk with your doctor:
  • Fever
  • Feeling dizzy or lightheaded

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