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Alloopurinol vs Probenecid risk of kidney damage

Can you show me literature/studies documenting that one is worse than another for treating gout in patients concerned about their kidneys. I have several experiences of creatinine returning to normal after starting Probenicid and Allopurinol. I have h...
by Elizabeth S. Hawkins in Baton Rouge,LA 70809, 05/04/2006

PROBENECID/COLCHICINE (Oral) (Tablet) Drug and Prescription Information


PROBENECID/COLCHICINE (Oral) (Tablet) Medication Classification


PROBENECID/COLCHICINE (Oral) (Tablet) Brandname

PROBENECID/COLCHICINE (Oral) (Tablet) is used for the Treatment

Colchicine (KOL-chi-seen), Probenecid (proe-BEN-e-sid) Treats gouty arthritis and severe attacks of gout.

When To Not Use PROBENECID/COLCHICINE (Oral) (Tablet)

You should not use this medicine if you have ever had an allergic reaction to probenecid or colchicine, or if you are pregnant. You should not use aspirin while taking this medicine. Tell your doctor if you have ever had ulcers, kidney problems (including kidney stones), or blood disorders.

How Should You Use PROBENECID/COLCHICINE (Oral) (Tablet)


  • Your doctor will tell you how much to use and how often.
  • Do not start taking this medicine during an attack of gout. Wait until the attack has stopped.
  • May be taken with food to avoid stomach upset.
  • Drink 8 to 10 glasses of fluid (such as water, juice, or pop) every day while you take this medicine.
  • Your doctor also may recommend the use of antacids or potassium citrate.
  • If a dose is missed:
  • Take the missed dose as soon as possible.
  • If it is almost time for your next dose, wait until then to take your medicine and skip the missed dose.
  • You should not use two doses at the same time.

Proper PROBENECID/COLCHICINE (Oral) (Tablet) Storage

Store PROBENECID/COLCHICINE (Oral) (Tablet) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep PROBENECID/COLCHICINE (Oral) (Tablet) and all medications out of the reach of children.

What To Avoid While Using PROBENECID/COLCHICINE (Oral) (Tablet)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use aspirin; instead take acetaminophen (Tylenol®) for pain.
  • Avoid drinking alcohol while taking this medicine.

PROBENECID/COLCHICINE (Oral) (Tablet) Warnings

  • If you are breastfeeding, talk to your doctor before taking this medicine.
  • Avoid becoming pregnant while using this medicine. If you become pregnant, tell your doctor right away.
  • This medicine may cause incorrect results on certain blood or urine tests, such as those used by people with diabetes.

PROBENECID/COLCHICINE (Oral) (Tablet) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Itching and skin rash
  • Unexplained fever
  • Trouble breathing
  • Numbness or tingling in hands or feet
  • Fast heartbeat
  • Severe stomach pain or vomiting
  • Muscle weakness
  • Severe diarrhea
  • If you notice these less serious side effects, talk with your doctor:
  • Dizziness or headache
  • Flushed face
  • Nausea or diarrhea


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