Prempro (Oral)

Questions | Reviews ***

Weaning off of Prempro

I have been using Prempro very successfully to cure hot flashes which resulted in sleepless nights. I remember my doctor saying that to discontinue using Prempro, you have do it slowly but I never went into details. What is the best way to stop taking...
by Eleanor in Fair Lawn, NJ, 01/19/2006

Prempro (Oral) Drug and Prescription Information

Prempro (Oral)

Prempro (Oral) Medication Classification


Prempro (Oral) Brandname

Prempro, Premphase, Prempro Low Dose

Prempro (Oral) is used for the Treatment

Conjugated Estrogens (KON-joo-gated ES-troe-jenz), Medroxyprogesterone Acetate (me-DROKS-ee-proe-JES-te-rone AS-a-tate) Treats lack of estrogen and progestin in your body caused by menopause or removal of the ovaries. Also helps prevent osteoporosis (weak and brittle bones). This medicine is a combination of hormones.

When To Not Use Prempro (Oral)

You should not use this medicine if you have had an allergic reaction to estrogen or progestin, or if you have had a hysterectomy. You should not use this medicine if you have any unusual vaginal bleeding, blood clots, circulation problems, liver disease, cancer of the breast or uterus, or if you have had a stroke. Do not use this medicine if you are pregnant or breastfeeding.

How Should You Use Prempro (Oral)


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

Proper Prempro (Oral) Storage

Store Prempro (Oral) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Prempro (Oral) and all medications out of the reach of children.

What To Avoid While Using Prempro (Oral)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Prempro (Oral) Warnings

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you have diabetes, high blood pressure, high cholesterol, asthma, migraine headaches, seizures, heart failure, or depression, or gall bladder, kidney, or liver disease.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Long-term use of large doses of estrogens may increase your risk of some kinds of cancer, including breast cancer. Your doctor should examine your breasts for lumps and other changes on a regular schedule. Examine your breasts at home every month. If you have questions about cancer risks or breast self-examination, talk with your doctor.

Prempro (Oral) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Abnormal vaginal bleeding
  • Lump in your breast
  • Pain in your chest or lower leg (calf)
  • Severe headache
  • Severe stomach pain or swelling
  • Shortness of breath, coughing up blood
  • Sudden vision changes
  • Weakness or numbness in an arm or leg
  • Yellowing of skin or eyes
  • If you notice these less serious side effects, talk with your doctor:
  • Bloated feeling, weight gain, swelling in hands, feet, or ankles
  • Breast tenderness or swelling
  • Changes in sexual desire
  • Depression, dizziness
  • Mild nausea or vomiting

Prempro (Oral) Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:




Prempro (Oral)

Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: ***


Arshi, Arshi - 01/13/2014

Thank you for your response. What I am siekeng is Placebo, Cohort, Double-blinded, Longitudinal studies such as the one the WHI carried out. it was initially believed that the WHI would show benefit until it was stopped, realizing that the estrogen only arm did NOT show an increase in Breast Cancer and that Medroxyprogesterone was known as far back as the 1960s to be an overly powerful progestogen with significant risks. While I too utilize bioidentical HT in my practice (typically Vivelle and prometrium) I do inform my patients that, until such studies are carried out on along-term basis, I CANNOT absolutely tell them it is without risk, only that the benefit seems to outweigh any observed risks to date. Be well