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PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet) Drug and Prescription Information


PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet) Medication Classification



Duo-Vil 2-25, Duo-Vil 2-10

PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet) is used for the Treatment

Amitriptyline (a-mee-TRIP-ti-leen), Perphenazine (per-FEN-a-zeen) Treats anxiety and depression.


You should not use this medicine if you have ever had an allergic reaction to perphenazine, Compazine®, Mellaril®, amitriptyline (Elavil®), or other antidepressants. This medicine should not be taken with monoamine oxidase (MAO) inhibitors (Marplan®, Nardil®, Parnate®).



  • Your doctor will tell you how much medicine to take and how often.
  • You may take your tablets with food to avoid stomach upset.
  • If a dose is missed:
  • Take the missed dose as soon as possible.
  • If it is almost time (within 2 hours) for the next dose, skip the missed dose and return to your regular dosing schedule.
  • You should not use two doses at the same time.


Store PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet) and all medications out of the reach of children.

What To Avoid While Using PERPHENAZINE/AMITRIPTYLINE (Oral) (Tablet)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcohol.
  • Make sure your doctor knows if you are taking drugs that can make you sleepy such as cold or allergy medicine, sedative, or pain killers.


  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Talk to your doctor before taking this medicine if you have heart disease, liver disease, epilepsy, glaucoma, or any other medical problem.
  • While taking this medicine, avoid becoming overheated during exercise and hot weather; it can result in heat stroke. Don't stay out in the sun too long.
  • This medicine may cause drowsiness. Be careful when driving a car or operating heavy machines.
  • There is a risk of side effects that include muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.
  • If you have been taking this medicine for a long time or in large doses, ask your doctor before you stop taking the medicine. You may need to take less and less before stopping completely.


Call your doctor right away if you notice any of these side effects:

  • Irregular heartbeat
  • Trouble breathing
  • Loss of bladder control
  • Uncontrollable movement of the tongue, cheeks, jaw, or arms
  • Seizures
  • Fever, severe muscle stiffness
  • Skin rash, itching, swelling
  • Unusual bleeding or bruising
  • If you notice these less serious side effects, talk with your doctor:
  • Dizziness or drowsiness
  • Dry mouth, stuffy nose
  • Difficulty having sex
  • Constipation


Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: ****

Ease of Use: **

Overall Satisfaction: *****


Venkat, Venkat - 01/14/2014

I too have suffered stmpyoms of fybromyalgia since having pip implants in 2005, for the past 2 years i have been in agony every night with back pain but spreads into my hips and upper back cant really pinpoint an actual place, i feel like i have been in an accident everynight ,i wake up with stifness and unable to sleep past 4am the pain continues and slightly subsides when i get up, i have had an mri scan to see what the problem is but hardly anything going on apart from minor wear and tear and one lower joint i have had spinal injections in that area that havent worked either. i have pins and needles in my left arm that started last year and muscle spasms behind the left implant, my gp didnt know what it was but i still have it,as well as tirdness and my memory is fogged as well as the ripplling which is horrible. i have had an mri scan on the implants and as yet havent been told if they have ruptured but i am seeing the consultant next week to see about the removal and replacements, i really dont want them but i was very depressed before i had them and will look deformed if i dont have them put back in . for the pain during the night i take naproxen before i go to bed thats all the doctor will give me but they dont help at all. I too have read that it could be an imune system problem caused by the silicone used and also the silicone outer shell even if they havent leaked.! the site did say patient s improved when the implants were take out but not replaced. hope you get sorted ! x