Orfadin (Oral)

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Orfadin (Oral) Drug and Prescription Information

Orfadin (Oral)

Orfadin (Oral) Medication Classification


Orfadin (Oral) Brandname


Orfadin (Oral) is used for the Treatment

Nitisinone (nye-TIS-i-none) Treats a hereditary condition called tyrosinemia, which causes your body to produce too much of an amino acid called tyrosine. This condition can cause unwanted effects on the liver and kidneys. This medicine will not cure tyrosinemia, but can be used together with diet to control the amount of tyrosine in your body.

When To Not Use Orfadin (Oral)

You should not use this medicine if you have had an allergic reaction to nitisinone.

How Should You Use Orfadin (Oral)


  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • Carefully follow your doctor's instructions about any special diet. You may need to restrict or avoid dairy products, meats, fish, eggs, almonds, avocados, bananas, soy, pumpkin seeds, sesame seeds, and many other foods that contain tyrosine.
  • It is best to take this medicine on an empty stomach, at least one hour before a meal.
  • If you cannot swallow the capsule, you may open it and pour the medicine into a small amount of water or applesauce. Stir this mixture well and swallow it without chewing.
  • If you are giving this medicine to an infant, you may open the capsule and mix the medicine with a small amount of liquid baby formula.
  • Never share your medicine with anyone.
  • If a dose is missed:
  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

Proper Orfadin (Oral) Storage

Store Orfadin (Oral) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Orfadin (Oral) and all medications out of the reach of children.

What To Avoid While Using Orfadin (Oral)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Orfadin (Oral) Warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. You may also need to have regular eye examinations and ultrasounds of your liver. Be sure to keep all appointments.

Orfadin (Oral) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
  • Black, tarry stools
  • Dark-colored urine or pale stools
  • Fast heartbeat
  • Extreme thirst or hot, dry skin
  • Itchy, flaky, or peeling skin rash
  • Muscle weakness, mental changes, confusion, disorientation
  • Nausea, vomiting, loss of appetite, pain in the upper stomach
  • Problems with vision, or eyes feeling more sensitive to light
  • Raised or thickened skin areas on the palms of your hands or soles of your feet
  • Red, sore, painful, puffy, or irritated eyes
  • Seizures
  • Sudden stomach pain, constipation, vomiting
  • Unusual bleeding, bruising, or weakness
  • Yellow eyes or skin
  • If you notice these less serious side effects, talk with your doctor:
  • Changes in your menstrual periods
  • Feeling nervous or tired
  • Mild diarrhea, stomach pain

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