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OLANZAPINE/FLUOXETINE (Oral) (Capsule) Drug and Prescription Information


OLANZAPINE/FLUOXETINE (Oral) (Capsule) Medication Classification


OLANZAPINE/FLUOXETINE (Oral) (Capsule) Brandname


OLANZAPINE/FLUOXETINE (Oral) (Capsule) is used for the Treatment

Fluoxetine (floo-OX-e-teen), Olanzapine (oh-LAN-za-peen) Treats depression that is a part of bipolar disorder. This medicine contains a selective serotonin reuptake inhibitor (SSRI) antidepressant.

When To Not Use OLANZAPINE/FLUOXETINE (Oral) (Capsule)

You should not use this medicine if you have had an allergic reaction to olanzapine (Zyprexa®) or fluoxetine (Prozac®, Sarafem®). Do not use this medicine if you are also using thioridazine (Mellaril®) or an MAOI medicine (such as Parnate, Eldepryl®, Nardil®, or Marplan®), or if you have used an MAOI in the past 14 days. Do not use thioridazine (Mellaril®) or an MAOI for at least 5 weeks after you stop using Symbyax™.

How Should You Use OLANZAPINE/FLUOXETINE (Oral) (Capsule)


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
  • You may take this medicine with or without food.
  • If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

Proper OLANZAPINE/FLUOXETINE (Oral) (Capsule) Storage

Store OLANZAPINE/FLUOXETINE (Oral) (Capsule) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep OLANZAPINE/FLUOXETINE (Oral) (Capsule) and all medications out of the reach of children.

What To Avoid While Using OLANZAPINE/FLUOXETINE (Oral) (Capsule)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many kinds of medicines that might cause problems if you use them while you are using Symbyax™. For example, medicines that might cause liver problems, low blood pressure, or overheating. Make sure your doctor knows about all other medicines you are using.
  • Make sure your doctor knows if you are also using Imitrex®, Prilosec®, rifampin (Rifadin®), digitoxin, digoxin (Lanoxin®), a blood thinner such as warfarin (Coumadin®), other medicine for mental illness, medicine for Parkinson's disease (such as levodopa, Sinemet®, Stalevo®), pain or arthritis medicine, or medicine for seizures, depression, or anxiety.
  • Pain or arthritis medicines include aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Feldene®, Daypro®, Motrin®, Orudis®, Relafen®, Voltaren®. Some medicines for seizures are carbamazepine, phenytoin, Dilantin®, Tegretol®. Other medicines for mental illness include clozapine, fluvoxamine, haloperidol, lithium, tryptophan, Clozaril®, Haldol®, Luvox®. Amitriptyline, desipramine, imipramine, nortriptyline are other medicines that treat depression. Medicines for anxiety include diazepam, Librium®, Valium®.
  • Make sure your doctor knows if you are also using blood pressure medicine. Some blood pressure medicines are atenolol, lisinopril, metoprolol, Cozaar®, Diovan®, Lotrel®, Norvasc®, Prinivil®, Toprol®, Zestril®. Hydrochlorothiazide (HCTZ) is another blood pressure medicine.
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you are also using any other medicine that contains olanzapine or fluoxetine. Some other brand names are Zyprexa®, Zyprexa® Zydis®, Prozac®, Prozac® Weekly, or Sarafem®.

OLANZAPINE/FLUOXETINE (Oral) (Capsule) Warnings

  • Make sure your doctor knows if you are pregnant, or if you have diabetes or a family history of diabetes. Tell your doctor about any forgetfulness or confusion related to aging (such as Alzheimer's disease or other kind of dementia). Make sure your doctor knows if you have seizures, liver disease, prostate problems, narrow-angle glaucoma, trouble swallowing, or a history of breast cancer or paralytic ileus (a digestion problem). Your doctor needs to know if you have any kind of heart or circulation problems, including heart disease, low blood pressure, high blood pressure, heart failure, heart rhythm problems, or a history of heart attack or stroke.
  • Do not breast feed while you are using this medicine.
  • If you develop new hives or a skin rash, even a mild one, stop using this medicine and call your doctor right away.
  • You might get overheated while using this medicine. Drink plenty of water during hot weather, while exercising, or while using a hot tub or sauna. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might have an upset stomach or vomit. Call your doctor if drinking cool water and moving away from the heat does not cool you down.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • If your symptoms do not improve or if they get worse, call your doctor.

OLANZAPINE/FLUOXETINE (Oral) (Capsule) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate.
  • Fast, slow, uneven, or pounding heartbeat.
  • Feeling very thirsty, hungry, or weak.
  • Fever, unusual sweating, or feeling too hot.
  • Light-headedness, dizziness, fainting.
  • Muscle stiffness, spasms, twitching, or other muscle movements you cannot control (especially in your face or mouth).
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Trouble breathing or swallowing.
  • Trouble sleeping, racing thoughts, feeling very nervous, energetic, restless, or having unusual or severe confusion.
  • If you notice these less serious side effects, talk with your doctor:
  • Diarrhea.
  • Dry mouth, sore throat, or hoarseness.
  • Mild muscle pain or shaking.
  • Mild weakness or trouble concentrating.
  • Swelling in your hands, ankles, or feet.
  • Trouble having sex.
  • Weight gain, eating more than usual.

OLANZAPINE/FLUOXETINE (Oral) (Capsule) Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: ***

Ease of Use: *****

Overall Satisfaction: *


Antonio, Antonio - 01/15/2014

My girl takes a combination oxacrbazpine (trileptal), sertraline (zoloft), and melatonin for sleep. She also sees a psychologist/therapist every 2 weeks and of course is dealing with the trials and troubles of her freshman year of highschool. She has a diagnosis of Borderline Personality Disorder. The symptons or BPD and Bipolar are so closely related often times it will mask as each other until later in the teen years when the symptoms start to delineate. Also I am told that bipolar can and often comes as episodes that ebb and flow as the youngster gets older; BPD is a constant state of mind that must actively use coping skills to retrain the thought process and self preceptions. We have learned not to be afraid of it and to face this head-on and understand that life will have some emotionally draining challenges, but also seeing the applications of what she is learning and seeing those small steps of progress is encouraging. Pay attention to the small steps forward and understand that only hindsight will provide the ability to see the progress forward... I want, pray and hope for only good things for you all. My God is a loving and faithful God that is in control of everything - I trust Him that things will get better. Its the journey that helps us grow - not the destination. Keep me informed and let me know if you need one of my shoulders or ears. (((hugs))