Questions | Reviews ***~

effects on the liver

  I am curious about the effects of Nortriptyline on the liver. I have taken this drug for some time. I recently had blood work showing higher than normal liver enzymes. I have heard that tricyclic drugs are harmful to the liver. Is this true?
by Grace Marshall in Fredericksburg Va., 05/20/2009

NORTRIPTYLINE (Oral) (Capsule Drug and Prescription Information


NORTRIPTYLINE (Oral) (Capsule Medication Classification


NORTRIPTYLINE (Oral) (Capsule Brandname

Pamelor, Aventyl HCl

NORTRIPTYLINE (Oral) (Capsule is used for the Treatment

Nortriptyline (nor-TRIP-ti-leen) Treats depression. It is also used to treat various types of pain. Belongs to a class of drugs called tricyclic antidepressants.

When To Not Use NORTRIPTYLINE (Oral) (Capsule

You should not use this medicine if you have had an allergic reaction to nortriptyline or other tricyclic antidepressants (such as Elavil®, Sinequan®, or Tofranil®), maprotiline (Ludiomil®), or trazodone (Desyrel®). You should not use this medicine if you have used a monoamine oxidase (MAO) inhibitor (such as Nardil®, Marplan®, Parnate®) within the past 14 days. You should also not use this medicine if you have just had a heart attack.

How Should You Use NORTRIPTYLINE (Oral) (Capsule

Capsule, Liquid

  • Your doctor will tell you how much medicine to use and how often.
  • May be taken with or without food.
  • If a dose is missed:
  • If more than one dose a day is used, use the missed dose as soon as possible unless it is almost time for your next dose.
  • You should not use two doses at the same time.
  • If only one dose at bedtime is used, you should not use the missed dose in the morning.

Proper NORTRIPTYLINE (Oral) (Capsule Storage

Store NORTRIPTYLINE (Oral) (Capsule at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep NORTRIPTYLINE (Oral) (Capsule and all medications out of the reach of children.

What To Avoid While Using NORTRIPTYLINE (Oral) (Capsule

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using Tagamet®, Antabuse®, or thyroid medicine.
  • Do not drink alcohol with this medicine.
  • Make sure your doctor knows if you are using other medicines that make you sleepy such as sleeping pills, cold or allergy medicine, sedatives, tranquilizers, or narcotic pain killers.

NORTRIPTYLINE (Oral) (Capsule Warnings

  • Talk to your doctor before using if you are pregnant, breastfeeding, or have a history of heart disease, glaucoma, epilepsy, or stomach problems.
  • If you are using this drug for depression, it may take 2 or 3 weeks of treatment before you start to feel better.
  • Nortriptyline may increase or decrease blood sugar levels.
  • Do not stop using nortriptyline suddenly. You may need to use smaller and smaller doses before completely stopping. Check with your doctor.
  • This medicine may cause drowsiness, especially during the first few weeks you are using it. Be careful when driving a car or operating machinery.
  • The oral solution (liquid) has alcohol in it.

NORTRIPTYLINE (Oral) (Capsule Side Effects

Call your doctor right away if you notice any of these side effects:

  • Severe confusion
  • Hallucinations
  • Hives, or swelling of face, lips, or tongue
  • Trouble going to the bathroom (urinating)
  • Unexplained or sore throat
  • If you notice these less serious side effects, talk with your doctor:
  • Drowsiness or dizziness
  • Constipation
  • Dry mouth
  • Nausea
  • Blurred vision
  • Sensitivity to sunlight

NORTRIPTYLINE (Oral) (Capsule Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:





Effectiveness: ***

Ease of Use: **

Overall Satisfaction: ***


Amanda, Amanda - 01/15/2014

Yikes on the diagnosis but I think you're dtefnieily on a great track trying to let food be thy medicine. I honestly always thought cheese would be the reason I could never go vegan, but it passes, I swear. And I don't know if they'd be Paleo, but daiya makes a havarti-like block of vegan cheese that's actually a not bad substitute for when I do think I need something like a big ole slab of cheese. [obviously it's processed, but...]So since I bailed on you Sat, I guess I owe you a date. Lemme know if you want to go for coffee Um, tea . Sometime?