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MERCAPTOPURINE (Oral) (Tablet) Drug and Prescription Information


MERCAPTOPURINE (Oral) (Tablet) Medication Classification


MERCAPTOPURINE (Oral) (Tablet) Brandname


MERCAPTOPURINE (Oral) (Tablet) is used for the Treatment

Mercaptopurine (mer-kap-toe-PYOOR-een) Treats leukemia.

When To Not Use MERCAPTOPURINE (Oral) (Tablet)

You should not use this medicine if you had an allergic reaction to mercaptopurine or thioguanine, or if you have ever been treated with mercaptopurine or thioguanine (Tabloid®) and the medicines did not work. You should not use mercaptopurine if you are pregnant.

How Should You Use MERCAPTOPURINE (Oral) (Tablet)


  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
  • If a dose is missed:
  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.

Proper MERCAPTOPURINE (Oral) (Tablet) Storage

Store MERCAPTOPURINE (Oral) (Tablet) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep MERCAPTOPURINE (Oral) (Tablet) and all medications out of the reach of children.

What To Avoid While Using MERCAPTOPURINE (Oral) (Tablet)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using a blood thinner (Coumadin®), allopurinol (Zyloprim®), cotrimoxazole (Bactrim®), olsalazine (Dipentum®), mesalamine (Asacol®), or sulfasalazine (Azulfidine®).
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving mercaptopurine. Vaccines may not work as well while you are using this medicine.

MERCAPTOPURINE (Oral) (Tablet) Warnings

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, kidney disease, gout, or inflammatory bowel disease.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

MERCAPTOPURINE (Oral) (Tablet) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Bloody or black, tarry stools
  • Dark-colored urine or pale stools
  • Nausea, vomiting, diarrhea, loss of appetite, pain in the upper stomach
  • Severe pain or swelling in your joints
  • Unexplained fever, sore throat, chills
  • Unusual bleeding, bruising, or weakness
  • Yellow skin or eyes
  • If you notice these less serious side effects, talk with your doctor:
  • Darkening of skin color
  • Mild diarrhea
  • Mild skin rash

MERCAPTOPURINE (Oral) (Tablet) Ratings

Overall Rating:



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Ease of Use:


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Effectiveness: *

Ease of Use: *

Overall Satisfaction: *****


Salvador, Salvador - 01/13/2014

Hey, I have just come across your blog via a tweet to Dynamo! As I write this I am lying in my hpaoitsl bed, where I have been for past 4 weeks with my monstrous crohns. I have the rarer gastro-duodenal crohns, which causes severe ulcers and subsequently severe anaemia. What has shocked me about your posts and other's comments is the poor level of pain relief you appear to be offered. I too am a GI specialist nurse and never would diclofenac be prescribed for an ulcerative condition! I am prescribed paracetamol, dihydrocodeine and oramorph. Any time I'm admitted (such as now) I am prescribed IV morphine 5mg 2 hourly. I don't take it 2 hourly, but it is prescribed that way to ensure I am never in pain. I must say too that this is the pain protocol here for all crohns, not specifically gastro duodenal. You must be in agony at times. I responded very well to mercaptopurine too, however, it was ultimately too toxic for me and caused a fierce pancreatitis. Am now 2 doses in on Infliximab. Also, does anyone on inflix have PICC lines or other long term access? I do, it has made life a lot easier. My access is terrible after the amount of IV's and blood tests, and was being subjected to femoral stabs everytime I needed a blood test, and I required central lines (jugular and subclavian) every time I was admitted. Anyway, better go, nurses are coming with my IV's. So nice to know others are going through the same and I'm not alone in the misery that is crohns. Laters!