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MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Drug and Prescription Information


MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Medication Classification


MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Brandname

Lunelle Monthly Contraceptive

MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) is used for the Treatment

Estradiol (es-tra-DYE-ole), Medroxyprogesterone (me-DROKS-ee-proe-JES-te-rone) Prevents pregnancy. This medicine is a form of birth control (contraception).

When To Not Use MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable)

You should not receive this medicine if you have had an allergic reaction to medroxyprogesterone or estradiol, if you may be pregnant, or if you have ever had blot-clotting problems, coronary artery disease, stroke, certain types of cancer, liver disease, or vaginal bleeding that has not been checked by your doctor. Under certain conditions, you should not receive this medicine if you have diabetes, high blood pressure, severe headaches, problems with your heart valves, or if you smoke.

How Should You Use MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable)


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other trained health professional will give you this medicine.
  • Your first shot must be given during the first 5 days of your menstrual cycle, or at least 4 weeks after having a baby.
  • If a dose is missed:
  • This medicine needs to be given on a re

Proper MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Storage

Store MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) and all medications out of the reach of children.

What To Avoid While Using MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine for seizures (such as Depakote®, Dilantin®), antibiotics (such as ampicillin, tetracycline, or griseofulvin (Grifulvin®)), St. John's Wort, rifampin (Rifadin®), phenylbutazone, cyclosporine (Sandimmune®, Neoral®), prednisolone, theophylline, Tylenol®, temazepam (Restoril®), morphine, or clofibric acid.

MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Warnings

  • Make sure your doctor knows if you are breastfeeding, or if you have diabetes, blood vessel disorders, high cholesterol, heart disease, liver disease, kidney disease, gall bladder problems, family history of breast cancer, or a history of depression.
  • This medicine may increase or decrease the length or heaviness of your menstrual periods. After your body has settled into a pattern of regular cycles, call your doctor if there is a change in this pattern.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine for several weeks before you have surgery or any other condition that keeps you in bed for a while.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.

MEDROXYPROGESTERONE/ESTRADIOL (Injection) (Injectable) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
  • Chest pain
  • Coughing up blood
  • Severe abdominal pain, yellow skin or eyes
  • Severe headache, trouble speaking, weakness or numbness in an arm or leg
  • Severe mood changes
  • Sharp pain in lower leg
  • Very heavy vaginal bleeding, either sudden or ongoing
  • Vision changes, loss of vision, double vision, protruding eyes
  • If you notice these less serious side effects, talk with your doctor:
  • Breast tenderness or pain
  • Swelling in your hands, ankles, or feet
  • Trouble wearing contact lenses
  • Weight gain

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