ERGOTAMINE/CAFFEINE (Rectal) (Suppository)

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ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Drug and Prescription Information

ERGOTAMINE/CAFFEINE (Rectal) (Suppository)

ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Medication Classification


ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Brandname

Migergot, Cafergot

ERGOTAMINE/CAFFEINE (Rectal) (Suppository) is used for the Treatment

Caffeine (kaf-EEN), Ergotamine (er-GOT-a-meen) Treats or prevents migraine and cluster headaches.

When To Not Use ERGOTAMINE/CAFFEINE (Rectal) (Suppository)

You should not use this medicine if you have had an allergic reaction to ergotamine or caffeine, or if you are pregnant or plan to become pregnant. You should not use this medicine if you have high blood pressure, kidney disease, liver disease, heart disease, blood vessel disorders, or problems with circulation.

How Should You Use ERGOTAMINE/CAFFEINE (Rectal) (Suppository)


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. Never take rectal suppositories by mouth.
  • Wash your hands with soap and water before using this medicine. Remove the foil or wrapper from the suppository before inserting it.
  • To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).
  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.
  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

Proper ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Storage

Store ERGOTAMINE/CAFFEINE (Rectal) (Suppository) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep ERGOTAMINE/CAFFEINE (Rectal) (Suppository) and all medications out of the reach of children.

What To Avoid While Using ERGOTAMINE/CAFFEINE (Rectal) (Suppository)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using dopamine (Intropin®), sibutramine (Meridia®), antibiotics (such as Biaxin®, Dynabac®, Ery-Tab®), blood pressure medicine (such as atenolol, metoprolol, Inderal®, Toprol®), medicines to treat HIV/AIDS (Agenerase®, Crixivan®, Invirase®, Norvir®, Rescriptor®, Sustiva®, Viracept®), or other medicines to treat migraine headaches (Amerge®, Imitrex®, Maxalt®, Zomig™).
  • Do not drink alcohol while you are using this medicine. Avoid caffeine (coffee, tea, soft drinks, chocolate).
  • Smoking may make your headaches worse or increase the side effects of this medicine.

ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Warnings

  • Make sure your doctor knows if you are breastfeeding, or if you have a stomach ulcer, glaucoma, or history of a stroke.
  • If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

ERGOTAMINE/CAFFEINE (Rectal) (Suppository) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Fast or slow heartbeat
  • Lightheadedness or fainting
  • Numbness or tingling in your fingers or toes
  • Pain or discomfort behind your breastbone
  • Pain, itching, or irritation around your rectum
  • Skin rash, swelling, or itching
  • Vomiting, numbness, tingling feeling, or pain and blue discoloration of your hands and feet
  • If you notice these less serious side effects, talk with your doctor:
  • Muscle pain
  • Nausea, vomiting, diarrhea, or stomach pain
  • Nervousness, irritability, dizziness
  • Weakness in your legs

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