DIHYDROERGOTAMINE (Injection) (Injectable)

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DIHYDROERGOTAMINE (Injection) (Injectable) Drug and Prescription Information

DIHYDROERGOTAMINE (Injection) (Injectable)

DIHYDROERGOTAMINE (Injection) (Injectable) Medication Classification


DIHYDROERGOTAMINE (Injection) (Injectable) Brandname

D.H.E. 45

DIHYDROERGOTAMINE (Injection) (Injectable) is used for the Treatment

Dihydroergotamine (dye-hye-droe-er-GOT-a-meen) Treats migraine headaches. Belongs to a class of drugs called ergot alkaloids.

When To Not Use DIHYDROERGOTAMINE (Injection) (Injectable)

You should not use this medicine if you have had an allergic reaction to dihydroergotamine or related medicines that contain ergotamine or ergot. You should not use it if you are pregnant or breastfeeding, or if you have heart or circulation problems, chest pain (angina), a blood infection, severe high blood pressure, or kidney or liver disease.

How Should You Use DIHYDROERGOTAMINE (Injection) (Injectable)


  • Your doctor will tell you how much medicine to use and how often.
  • You may be told to use the medicine at the first sign of a migraine headache.
  • An IM injection is a shot given in your muscle (upper arm, thigh, buttocks).
  • A doctor, nurse, or other health caregiver will teach you how to give yourself the shots. You may want a family member or friend to also learn how to give your medicine.
  • If a dose is missed:
  • Dihydroergotamine is used when you have a migraine. It is not used on a regular schedule.

Proper DIHYDROERGOTAMINE (Injection) (Injectable) Storage

Store DIHYDROERGOTAMINE (Injection) (Injectable) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep DIHYDROERGOTAMINE (Injection) (Injectable) and all medications out of the reach of children.

What To Avoid While Using DIHYDROERGOTAMINE (Injection) (Injectable)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Talk to your doctor before using this medicine if you are using decongestants (such as pseudoephedrine or phenylpropanolamine), midodrine, diet pills, or if you use other medicine to treat migraines (such as sumatriptan (Imitrex®) or zolmitriptan (Zomig®).
  • Make sure your doctor knows if you are using propranolol (Inderal®), medicine for your heart, or antibiotics for an infection (such as erythromycin or clarithromycin).
  • It is best not to smoke tobacco while using this medicine. Smoking may increase side effects of the medicine.

DIHYDROERGOTAMINE (Injection) (Injectable) Warnings

  • You should not use more of this medicine that your doctor ordered.
  • This medicine helps stop migraine headaches. It does not relieve pain or stop other kinds of headaches.
  • Do not get pregnant while you are being treated with this medicine. Dihydroergotamine may cause birth defects or be harmful to an unborn baby.
  • This medicine may make you dizzy or drowsy. Avoid driving or using machinery until you know how the medicine will affect you.

DIHYDROERGOTAMINE (Injection) (Injectable) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Coldness, numbness, tingling, or a blue color in your fingers and toes
  • Hives, rash, severe itching
  • Muscle pain in your arms and legs
  • Weakness in your legs
  • Chest pain
  • Fast, slow, or irregular heartbeat
  • Wheezing or trouble breathing
  • Swelling in your face, hands, legs, or feet
  • If you notice these less serious side effects, talk with your doctor:
  • Mild nausea and vomiting
  • Mild itching
  • Flushing, sweating
  • Feeling dizzy or drowsy

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