Depo-Medrol (Injection)

Questions | Reviews *

Dosage for one injection? [in knee joint]

How much is the dosage of Depo-Medrol for one injection in knee joint? I'm not sure what the correct dosage would be and cannot find information about it anywhere. Thanks for any information.
by Dave Kaplan in Winnipeg, Manitoba, Canada, 11/18/2005

change in mood

Does the shot cause more servere mood swings?
by Missie in US, 08/20/2008

depo medrol

Please read Okay so i work at a veternary hospital and i just got some depo medrol can this make my muscles bigger if i work out on it. adrenal steroid
by ryan in Allen, TX, 02/04/2009

what are the benefits?

Dear sir/madam, I am Zoya Khan and i am working as a transcriptionist.  I have been working for the past three years and i am suffering with wrist pain, weakness, fatigue etc. I want some suggestion: Three months before i have...
by Zoya Khan in Andhra Pradesh, India, 11/08/2006

Dep-Medrol Injection

My mother has carpal tunnel syndrome for last 3 years. Doctors advised her surgery of both hands to relieve stressed Carpal Tunnel in both the wrist sites. She did not so far undergo surgery. She also suffers muscular and some join pains in the whole ...
by Shabbir in Canada, 10/12/2006

Depo-Medrol (Injection) Drug and Prescription Information

Depo-Medrol (Injection)

Depo-Medrol (Injection) Medication Classification


Depo-Medrol (Injection) Brandname

Depo-Medrol, Solu-Medrol, A-Methapred

Depo-Medrol (Injection) is used for the Treatment

Methylprednisolone (meth-il-pred-NIS-oh-lone) Treats inflammation, flare-ups of ongoing illnesses, and many other medical problems. May also be used to lessen some symptoms of cancer. This medicine is a steroid.

When To Not Use Depo-Medrol (Injection)

You should not use this medicine if you have had an allergic reaction to methylprednisolone or if you have a fungal infection. Some strengths of Solu-Medrol® should not be used in premature babies.

How Should You Use Depo-Medrol (Injection)


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle, vein, or joint, or under the skin.
  • A nurse or other trained health professional will give you this medicine. It may also be given by a home health caregiver. You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Use a new needle and syringe each time you inject your medicine. never share your medicine with anyone.
  • If a dose is missed:
  • This medicine will work best if you use it exactly as your doctor has ordered. If you do miss a dose, call your doctor or pharmacist for instructions.

Proper Depo-Medrol (Injection) Storage

Store Depo-Medrol (Injection) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Depo-Medrol (Injection) and all medications out of the reach of children.

What To Avoid While Using Depo-Medrol (Injection)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using aspirin, cyclosporine (Sandimmune®, Neoral®), phenobarbital (Luminol®), phenytoin (Dilantin®), rifampin (Rifadin®), ketoconazole (Nizoral®), troleandomycin (TAO®), pancuronium (Pavulon®), high-dose aspirin, a blood thinner such as warfarin (Coumadin®), or diabetes medicine (insulin or oral medicine such as Avandia®, Glucophage®).
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving methylprednisolone. Vaccines may not work as well while you are using this medicine.

Depo-Medrol (Injection) Warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have high blood pressure, blood clotting problems, tuberculosis, Strongyloides (threadworm) infection, ulcers, thyroid problems, liver disease, mental or emotional problems, eye disease (especially herpes), stomach or digestive problems, osteoporosis, or myasthenia gravis or other nerve-muscle problems. If this medicine is being injected into a joint, make sure your doctor knows about any other problems you have had with that joint.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
  • Avoid people who are sick or have infections, because you may get sick more easily. If you are exposed to chickenpox or measles, tell your doctor right away.
  • Tell your doctor if you have any events causing unusual stress or anxiety in your life.
  • If your symptoms do not improve or if they get worse, call your doctor.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

Depo-Medrol (Injection) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
  • Headache, eye pain, or trouble seeing
  • Irregular or slow heartbeat, chest pain, dizziness
  • Muscle weakness or cramps
  • Seizures
  • Stomach problems, stomach pain, bloody or black stools
  • Sudden pain, swelling, or loss of movement in the lower leg
  • Swelling in your hands, ankles, or feet, rapid weight gain
  • If you notice these less serious side effects, talk with your doctor:
  • Mood changes, trouble sleeping, unusual behavior
  • Skin change where the shot is given
  • Weight gain, increased hair growth, roundness of the face, thinning skin, unusual bruising

Depo-Medrol (Injection) Ratings

Overall Rating:



(based on 1 review)



Ease of Use:


Overall Satisfaction:




Depo-Medrol (Injection)

Effectiveness: *

Ease of Use: *

Overall Satisfaction: *


bobby, minnesota - 06/02/2012

It is horrible!!! As bad if not worse than th pain I received it for....and in less than 24 hours after injection, I got cellulitous at the injection site...mow my body feels so heavy, especially my hand and arm it was given in...low grade temp...I will not be trying this again and would not recomend it to anyone.