Depakote ER (Oral)

Questions | Reviews ***~

is this an maoi inhibitor

I am interested in taking weight loss pills and I need to know if I will have adverse side effects due to mixing the two drugs. Thank you ,Ian  
by ian banker in st. charles il, 07/29/2006

Is Depakote ER for Children?

I am wanting to know if this is for a child who is 6 years old? My step-child is taking this med. and we would like to know the side effects and why a child this young would be taking this med. Please tell me all the information that you have on this ...
by Angie in Albany, GA, 08/06/2006

breastfeeding while on depakote ER

Two weeks ago i had a baby and am breastfeeding. I started on depakote ER one week ago and it seems to have slowed down lactation. Have you heard of this side effect before? My baby is not gaining the weight he is supposed to. So i was wonde...
by addie callahan in salem, oregon, USA, 08/14/2007

How to give Depakote sprinkles to a child that can't swallow.

I have a 7 year old student who is taking Depakote Sprinkles but he cannot swallow much. I do not know how he really gets because he drools alot. He gets all nutrition through a gastrointestinal tube. I usually open the capsule and put it under his to...
by Alicia Robinson in Philadelphia, Pa, 10/11/2006

Depakote ER (Oral) Drug and Prescription Information

Depakote ER (Oral)

Depakote ER (Oral) Medication Classification


Depakote ER (Oral) Brandname

Depakote, Depakote ER, Depakote Sprinkles

Depakote ER (Oral) is used for the Treatment

Divalproex Sodium (dye-VAL-pro-ex SO-dee-um) Treats seizures (epilepsy). Also used to treat mood disorders and prevent migraine headaches. Belongs to a class of drugs called anticonvulsants.

When To Not Use Depakote ER (Oral)

You should not use this medicine if you have had an allergic reaction to valproic acid or divalproex in the past, if you have severe liver disease, or if you are pregnant.

How Should You Use Depakote ER (Oral)

Long Acting Tablet, Coated Tablet, Delayed Release Capsule

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • May be taken with food to lessen stomach upset.
  • Swallow the capsule or tablet whole. Do not crush, break or chew.
  • You may open the sprinkle capsule and mix the medicine beads with a small amount (about a spoonful) of soft food such as applesauce or pudding. Swallow the mixture whole. Do not chew.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
  • If you miss two or more doses, call your doctor.

Proper Depakote ER (Oral) Storage

Store Depakote ER (Oral) at room temperature away from sunlight and moisture unless otherwise stated by manufacturer's instructions or labelling. Keep Depakote ER (Oral) and all medications out of the reach of children.

What To Avoid While Using Depakote ER (Oral)

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcohol.
  • Make sure your doctor knows if you are taking "blood thinners" (medicines such as aspirin or Coumadin®) or if you are taking other medicines that could make you sleepy such as sleeping pills, cold medicine, or sedatives.

Depakote ER (Oral) Warnings

  • Check with your doctor before taking this medicine if you are breastfeeding, have liver or kidney disease or blood disorders.
  • Talk to your doctor before taking this medicine if you are pregnant. If you become pregnant while being treated with this medicine, tell your doctor right away. This medicine may be harmful to your unborn baby.
  • Because of the risk of increased seizures, do not suddenly stop taking this medicine without first checking with your doctor.
  • If you are taking this medicine in the form of sprinkles, you may see small amounts of the coating in your stool. This is normal.
  • This medicine may cause drowsiness. Be careful when driving or using machinery.

Depakote ER (Oral) Side Effects

Call your doctor right away if you notice any of these side effects:

  • Loss of seizure control
  • Severe weakness or dizziness
  • Severe vomiting that doesn't go away
  • Unusual bleeding or bruising
  • Yellowing of the skin or eyes
  • Rash or hives with itching
  • If you notice these less serious side effects, talk with your doctor:
  • Nausea, vomiting, or stomach cramps
  • Drowsiness or dizziness
  • Restlessness or irritability
  • Diarrhea or constipation
  • Trembling of hands or arms
  • Hair loss

Depakote ER (Oral) Ratings

Overall Rating:



(based on 6 reviews)



Ease of Use:


Overall Satisfaction:




Depakote ER (Oral)

Effectiveness: **

Ease of Use: *****

Overall Satisfaction: *


Tony, Oakville, ON - 11/01/2008

Depakote ER Oral’s side effects had a major impact on my day to day life. This medication increased my appetite and as a result, I gained over 40 lbs. My libido had depleted, so sexual aspects of my life were affected. I was irritable, and this medication made me extremely tired. I was still getting migraines. I requested my lab work be sent to my primary doctor. I was told my liver profile was comparable to that of someone who was going to have liver failure. My primary doctor insisted that I stop taking this medication. I went back to the specialist and he felt that my primary doctor and I were challenging his knowledge. Yet, he agreed to take me off the medication. Unfortunately, there was no other replacement medication. In closing, I don’t feel that this medicine was worth the serious impact it had on my life. In addition to the problems listed, the cost of the medication was an issue as well.

Depakote ER (Oral)

Effectiveness: ***

Ease of Use: ****

Overall Satisfaction: ***


Tania, pune - 01/29/2010

I have been on this medication after coming off of Topamax. I am taking a dose of 500mg, and so far I feel pressure in my head, but not the vomiting or full-on migraines. I also take other medication for my migraines.

Depakote ER (Oral)

Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****


nasirabbas, Brunswick, Maine - 03/02/2010

I have been taking Depakote Oral for a month now. I have been taking Lithium for 8 months as well. Depakote has helped curb my spending sprees and nervousness. With Lithium, I was still nervous. However, Depakote has surely helped with both. I was a little irritable in the beginning of my medicine regiment, but it has since become better. It also helps with the headaches that I was having.

Depakote ER (Oral)

Effectiveness: ****

Ease of Use: *****

Overall Satisfaction: ****


brooklyn, jamaica - 03/16/2009

While taking this drug I've gained a little weight, but I'm happy with the results as I'm quite stable.