Zolpidem tartrate

Questions | Reviews ***

Shortness of breath as possible side effect of Zolpidem tartrate?

I have been taking Zolpidem tartrate for about 2 years. In the beginning now and again, in the last few months half a 10mg tablet every night. For years I have suffered from occasional asthma and a general, but mild shortness of breath, due to having ...
by lisa Parker in Australia, 05/05/2006

zolpidem 10 mg. with 516 on the tablet

My Zolpidem seems to be get larger in size when I have it refilled. The first refills looked like regular Ambien but now my tablet has double in size and as a #516 written on it. I'm a little afraid to take not knowing if this the right ones ...
by genie burns in salt lake city, ut., 07/21/2007

alternative for Ambien

What sleeping pill is a good alternative for Ambien that does not cause night eating?
by Mrs. Margot Journey in California, 05/02/2008

Zolpidem tartrate

what would happen if i took instead of 1 pill of Zolpidem Tartrate and took 2 by mistake?
by Arnaldo in Bronx NY, 11/08/2007

Zolpidem tartrate
Zolpidem tartrate (Ambien)
Zolpidem tartrate
( ZOL-pih-dem)
Pregnancy Category: B Ambien (Rx) (C-IV)

Classification: Nonbarbiturate, nonbenzodiazepine sedative-hypnotic

Action/Kinetics: May act by subunit modulation of the GABA receptor chloride channel macromolecular complex resulting in sedative, anticonvulsant, anxiolytic, and myorelaxant properties. Although unrelated chemically to the benzodiazepines or barbiturates, it interacts with a GABA-benzodiazepine receptor complex and shares some of the pharmacologic effects of the benzodiazepines. Specifically, it binds the omega-1 receptor preferentially. No evidence of residual next-day effects or rebound insomnia at usual doses; little evidence for memory impairment. Sleep time spent in stage 3 to 4 (deep sleep) was comparable to placebo with only inconsistent, minor changes in REM sleep at recommended doses. Rapidly absorbed from the GI tract. t 1/2: About 2.5 hr (increased in geriatric clients and those with impaired hepatic function). Bound significantly (92.5%) to plasma proteins. Food decreases the bioavailability of zolpidem. Metabolized in the liver; inactive metabolites are excreted primarily through the urine.

Uses: Short-term treatment of insomnia.

Contraindications: Lactation.

Special Concerns: Use with caution and at reduced dosage in clients with impaired hepatic function, in compromised respiratory function, in those with impaired renal function, and in clients with S&S of depression. Impaired motor or cognitive performance after repeated use or unusual sensitivity to hypnotic drugs may be noted in geriatric or debilitated clients. Closely observe individuals with a history of dependence on or abuse of drugs or alcohol. Safety and efficacy have not been determined in children less than 18 years of age.

Side Effects: Symptoms of withdrawal: Although there is no clear evidence of a withdrawal syndrome, the following symptoms were noted with zolpidem following placebo substitution: fatigue, nausea, flushing, lightheadedness, uncontrolled crying, emesis, stomach cramps, panic attack, nervousness, abdominal discomfort.
The most common side effects following use for up to 10 nights included drowsiness, dizziness, and diarrhea. The side effects listed in the following are for an incidence of 1% or greater. CNS: Headache, drowsiness, dizziness, lethargy, drugged feeling, lightheadedness, depression, abnormal dreams, amnesia, anxiety, nervousness, sleep disorder, ataxia, confusion, euphoria, insomnia, vertigo. GI: Nausea, diarrhea, dyspepsia, abdominal pain, constipation, anorexia, vomiting. Musculoskeletal: Myalgia, arthralgia. Respiratory: URI, sinusitis, pharyngitis, rhinitis. Body as a whole: Allergy, back pain, flu-like symptoms, chest pain, fatigue. Ophthalmologic: Diplopia, abnormal vision. Miscellaneous: Rash, UTI, palpitations, dry mouth, infection.

Laboratory Test Alterations: ALT, AST, BUN. Hyperglycemia, hypercholesterolemia, hyperlipidemia, abnormal hepatic function.

Overdose Management: Symptoms: Symptoms ranging from somnolence to light coma. Rarely, CV and respiratory compromise. Treatment: Gastric lavage if appropriate. General symptomatic and supportive measures. IV fluids as needed. Flumazenil may be effective in reversing CNS depression. Monitor hypotension and CNS depression and treat appropriately. Sedative drugs should not be used, even if excitation occurs. Zolpidem is not dialyzable.

Drug Interactions: CNS depressants/ Additive CNS depression Ketoconazole / Plasma ketoconazole levels

How Supplied: Tablet: 5 mg, 10 mg

?Tablets Hypnotic.
Adults, individualized, usual: 10 mg just before bedtime. In hepatic insufficiency, use an initial dose of 5 mg.

Zolpidem tartrate Ratings

Overall Rating:



(based on 5 reviews)



Ease of Use:


Overall Satisfaction:




Zolpidem tartrate

Effectiveness: ***

Ease of Use: ****

Overall Satisfaction: *****


Rebecca, Atlanta - 10/22/2008

I have been taking Zolpidem Oral for nearly two months now. Overall, it helps me sleep well, but I'm concerned with the nightmares, not to mention the hallucinations I've been having lately before I finally fall asleep.

Zolpidem tartrate

Effectiveness: ***

Ease of Use: ****

Overall Satisfaction: **


Kevin, Flemington, New Jersey - 11/05/2010

After taking the drug for about eight months I started to notice it was not working as well as it used to. I decided to stop using it for a while to see what would happen. I am a sufferer of sleep apnea and have to wear a special mask and without taking the drug I am now waking every couple hours and have a difficult time falling asleep again. I am going to have to consult my physician to see if he can recommend something different as I believe I have become addicted to it and I would not recommend long term use of this drug to anyone.

1 comment | Reply


Jeff, Tupelo, MS - 12/31/2015

I am having the same problem, which has led me to your comment. Interested to see if you had any luck finding a replacement. I have been taking it about six months, and have sleep apnea as well. I have not taken it a couple of nights, and had a hard time falling to sleep, and when I did, I woke up several times. Hopefully you found something to use besides Zolpidem.