Tubocurarine chloride

Questions | Reviews ***

I am curious about the stability of tubocurarine chloride.

Hello. My name is Mitchell Shin and I am a researcher in a drug delivery systems lab of Seoul National University, Korea. Concerning with my work, I have some question of tubocurarine chloride injectible solution. I would like to know about the stabil...
by Mitchell Shin in Seoul, Korea, 10/29/2006

Mystery story research

Hello, I am writing a murder mystery and have questions about detecting the presence of tubocurarine chloride. If a nervous person accidently sprayed a bit on a painted/ wallpapered wall, would it leave a mark? Can you describe this mark, eg colour, a...
by Valerie MacNeill in Scotland (Linlithgow, Central Belt), 08/11/2006

Acquisition of Tubocurarine Chloride

I am interested in discovering where and how I can acquire some tubocurarine chloride - that is what companies I can get it from, the price, etc. Is this drug available from man companies or are there any generic forms of Tubocurarine Chloride that yo...
by Jason Nicholson in Calgary, Canada, 02/07/2006

Tubocurarine chloride
Tubocurarine chloride
Tubocurarine chloride
(too-boh-kyour- AR-een)
Pregnancy Category: C (Rx)

Classification: Nondepolarizing neuromuscular blocking agent

See Also: See also Neuromuscular Blocking Agents .

Action/Kinetics: Cumulative effects may occur. Most likely of the nondepolarizing drugs to cause histamine release. Narrow margin between therapeutic dose and toxic dose. Onset, IV: 1 min; IM: 15-25 min. Time to peak effect, IV: 2-5 min. Duration, IV: 20-90 min. t 1/2: 1-3 hr. About 43% excreted unchanged in urine.

Uses: Muscle relaxant during surgery or setting of fractures and dislocations; spasticity caused by injury to or disease of CNS. Treat seizures electrically induced or induced by drugs. Diagnosis of myasthenia gravis.

Additional Contraindications: Clients in whom release of histamine is hazardous.

Special Concerns: Use with caution during pregnancy and lactation and in children. If repeated doses are used before delivery, the newborn may manifest decreased skeletal muscle activity. Children up to 1 month of age may be more sensitive to the effects of tubocurarine. Use with extreme caution in clients with renal dysfunction, liver disease, or obstructive states.

Additional Side Effects: Allergic reactions. Excessive secretion and circulatory collapse.

Overdose Management: Treatment: Overdosage chiefly treated by artificial respiration, although neostigmine, atropine, and edrophonium chloride should also be on hand.

Additional Drug Interactions: Acetylcholine / Antagonizes effect of tubocurarine Anticholinesterases / Antagonizes effect of tubocurarine Calcium salts / Tubocurarine effect Diazepam / Risk of malignant hyperthermia Potassium / Antagonizes effect of tubocurarine Propranolol / Tubocurarine effect Quinine / Tubocurarine effect Succinylcholine chloride / Relaxant effect of both drugs

How Supplied: Injection: 3 mg/mL

?IV, IM Adjunct to surgical anesthesia.
Adults, IM, IV, initial: 6-9 mg (40-60 units); then, 3-4.5 mg (20-30 units) in 3-5 min if needed. Supplemental doses of 3 mg (20 units) can be given for prolonged procedures. Dosage can be calculated on the basis of 1.1 units/kg. Pediatric, up to 4 weeks of age, IV, initial: 0.3 mg/kg; then, give subsequent doses in increments of 1/5- 1/6 the initial dose. Infants and children, IV: 0.6 mg/kg.
Electroshock therapy.
Adults, IV: 0.165 mg/kg (1.1 units/kg) given over 30-90 sec. It is recommended that the initial dose be 3 mg less than the calculated total dose.
Diagnosis of myasthenia gravis.
Adults, IV: 0.004-0.033 mg/kg. A test dose should be given within 2-3 min with IV neostigmine, 1.5 mg, to minimize prolonged respiratory paralysis.

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