Tripelennamine hydrochloride

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My mother and I have used Pyribenzamine Hydrochloride for many, many years with great success.  Since the removal of this wonderful allergy relief medicine, we have tried Zyrtec, Claritin, Claritin-D, and Allegra.  Quite frankly, I am tired ...
by Tricia Oakley in Fort Bragg, CA, 03/24/2008

Tripelennamine hydrochloride
Tripelennamine hydrochloride (PBZ)
Tripelennamine hydrochloride
(try-pell- EN-ah-meen) PBZ PBZ-SR Pyribenzamine (Rx)

Classification: Antihistamine, ethylenediamine derivative

See Also: See also Antihistamines .

Action/Kinetics: GI effects more pronounced than other antihistamines. Moderate sedative effects and low to no anticholinergic activity. Duration: 4-6 hr.

Contraindications: Use in neonates.

Special Concerns: Safe use during pregnancy has not been established. Geriatric clients may be more sensitive to the usual adult dose.

Side Effects: Low incidence. Moderate sedation, mild GI distress, paradoxical excitation, hyperirritability.

How Supplied: Tablet: 25 mg, 50 mg; Tablet, Extended Release: 100 mg

Adults, usual: 25-50 mg q 4-6 hr; as little as 25 mg or as high as 600 mg may be given to control symptoms. Pediatric: 5 mg/kg/day or 150 mg/m 2/day divided into 4-6 doses, not to exceed 300 mg/day.
?Extended-Release Tablets
Adults: 100 mg q 8-12 hr as needed, up to a maximum of 600 mg/day. Do not use sustained-release form in children.

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