Triazolam


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Triazolam
Triazolam (Apo-Triazo , Halcion)
Triazolam
(try- AYZ-oh-lam)
Pregnancy Category: X Alti-Triazolam Apo-Triazo Gen-Triazolam Halcion Novo-Triolam (C-IV) (Rx)

Classification: Benzodiazepine sedative-hypnotic

See Also: See also Tranquilizers, Antimanic Drugs, and Hypnotics .

Action/Kinetics: Decreases sleep latency, increases the duration of sleep, and decreases the number of awakenings. Time to peak plasma levels: 0.5-2 hr. t 1/2: 1.5-5.5 hr. Metabolized in liver; inactive metabolites excreted in the urine.

Uses: Insomnia (short-term management, not to exceed 1 month). May be beneficial in preventing or treating transient insomnia from a sudden change in sleep schedule.

Contraindications: Use concomitantly with itraconazole, ketoconazole, nefaxodone. Lactation (may cause sedation and feeding problems in infants).

Special Concerns: Safety and efficacy in children under 18 years of age not established. Geriatric clients may be more sensitive to the effects of triazolam.

Side Effects: CNS: Rebound insomnia, anterograde amnesia, headache, ataxia, decreased coordination, ``traveler's'' amnesia. Psychologic and physical dependence. GI: N&V.

Drug Interactions: Triazolam effect when used with azole antifungals, clarithromycin, erythromycin, grapefruit juice, protease inhibitors, and selective serotonin reuptake inihibitors R/T liver metabolism.

How Supplied: Tablet: 0.125 mg, 0.25 mg

Dosage
?Tablets
Adults, initial: 0.25-0.5 mg before bedtime. Geriatric or debilitated clients, initial: 0.125 mg; then, depending on response, 0.125-0.25 mg before bedtime.

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