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Tolbutamide (Orinase)
(toll- BYOU-tah-myd)
Pregnancy Category: C APO-Tolbutamide Novo-Butamide Orinase (Rx)
Tolbutamide sodium
Tolbutamide sodium (Orinase Diagnostic)
(toll- BYOU-tah-myd)
Pregnancy Category: C Orinase Diagnostic (Rx)

Classification: Sulfonylurea, first-generation

See Also: See also Antidiabetic Agents: Hypoglycemic Agents .

Action/Kinetics: Onset: 1 hr. t 1/2: 4.5-6.5 hr. Time to peak levels: 3-4 hr. Duration: 6-12 hr. Changed in liver to inactive metabolites. Excreted through the kidneys.

Additional Uses: Most useful for clients with poor general physical status who should receive a short-acting compound.
Tolbutamide sodium is used to diagnose pancreatic islet cell tumors. It causes blood glucose, in the presence of a tumor, to drop quickly after IV administration and remain low for 3 hr.

Additional Side Effects: Melena (dark, bloody stools) in some clients with a history of peptic ulcer. Relapse or secondary failure may occur a few months after therapy has been started. May cause hyponatremia and a mild goiter.

Additional Drug Interactions: Alcohol / Photosensitivity reactions Sulfinpyrazone / Effect of tolbutamide due to breakdown by liver

How Supplied: Tolbutamide: Tablet: 500 mg; Tolbutamide sodium: Powder for injection: 1 g

?Tablets Diabetes mellitus.
Adults, initial: 1-2 g/day. Adjust dosage depending on response, up to 3 g/day. Usual maintenance: 0.25-3 g/day. A daily dose greater than 2 g is seldom required.

Tolbutamide Ratings

Overall Rating:



(based on 2 reviews)



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Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *


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