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Tolazamide (Tolinase)
(toll- AZ-ah-myd)
Pregnancy Category: C Tolinase (Rx)

Classification: Sulfonylurea, first-generation

See Also: See also Antidiabetic Agents: Hypoglycemic Agents .

Action/Kinetics: Effective in some with a history of coma or ketoacidosis; may be effective in clients who do not respond well to other oral antidiabetics. Use with insulin is not recommended for maintenance. Absorbed more slowly than other sulfonylureas. Onset: 4-6 hr. t 1/2: 7 hr. Time to peak levels: 3-4 hr. Duration: 12-24 hr. Metabolized in liver to metabolites with minor hypoglycemic activity. Excreted through the kidneys.

Additional Contraindications: Renal glycosuria.

Additional Drug Interactions: Concomitant use of alcohol and tolazamide may photosensitivity.

How Supplied: Tablet: 100 mg, 250 mg, 500 mg

?Tablets Diabetes.
Adults, initial: 100 mg/day if fasting blood sugar is less than 200 mg/100 mL, or 250 mg/day if fasting blood sugar is greater than 200 mg/100 mL. Adjust dose to response, not to exceed 1 g/day; adjust dosage in increments of 100-250 mg at weekly intervals based on client response. If more than 500 mg/day is required, give in two divided doses, usually before the morning and evening meals. Maintenance, average: 250-500 mg/day. Elderly, malnourished, underweight clients or those not eating properly: 100 mg once daily with breakfast, adjusting dose by increments of 50 mg/day each week. Doses greater than 1 g/day will probably not improve control.

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