Tizanidine hydrochloride

Questions | Reviews *~

QuotesChimp simply s

QuotesChimp simply shieldes these  4;perhaps not to blame 4; When a collision happens, solely the individual adjudged perhaps not responsible or less responsible (determined by the regulations of each and every condition) can get harms for thing...
by Kelenna in Kelenna, 03/06/2014

What are the side effects of TIZANIDINE 4 mg?

have leg pain called restless leg sydome. Is this tizanidine right for this pain?? I have taken requip but it doesent help
by Josephine B in West Virgunia, 05/08/2006

, there are plenty o

, there are plenty of times where the innruasce companies are just trying to nickle and dime their customers. Generic Topamax (topiramate) is fairly cheap. Safeway, for example, sells 180 of the 25 mg pills for less than $16. Cut the 50 mg pills in ha...
by Sande in Sande, 01/13/2014

Tizanidine hydrochloride

Hey! I was wondering does Tizanidine hydrochloride (zanaflex) show up on a drug test? And if it does , what does it show up as? I was wondering because I have random drug testing for my job & my doc gave me these for migraines. well than...
by Carrie in Birmingham , Al., 07/07/2007

weight gain

I've been taking Tizanidine for muscle spasms in my neck. I have MS and I feel my appetite has increased 180% yet, i do not see that as a side effect. Has anyone ever had this happen? I think I'm stopping tonight, I can't stand what my bod...
by Jodie in Pittsfield, MA, 05/30/2007

Tizanidine hydrochloride
Tizanidine hydrochloride (Zanaflex)
Tizanidine hydrochloride
(tye- ZAN-ih-deen)
Pregnancy Category: C Zanaflex (Rx)

Classification: Skeletal muscle relaxant, centrally-acting

See Also: See also Skeletal Muscle Relaxants, Centrally Acting.

Action/Kinetics: Acts on central -2 adrenergic receptors; reduces spasticity by increasing presynaptic inhibition of motor neurons possibly by reducing release of excitatory amino acids. Greatest effects are on polysynaptic pathways. Also may reduce postsynaptic excitatory transmitter activity, decrease the firing rate of noradrenergic locus ceruleas neurons, and inhibit synaptic transmission of nociceptive stimuli in the spinal pathways. Peak effect: 1-2 hr. Duration: 3-6 hr. Extensive first pass metabolism. t 1/2: About 2.5 hr. Excreted in urine and feces. Elderly clear drug more slowly.

Uses: Acute and intermittent management of muscle spasticity.

Contraindications: Use with -2-adrenergic agonists.

Special Concerns: Use with caution in renal impairment, in elderly and during laction. Use with extreme caution in hepatic insufficiency. Safety and efficacy have not been determined in children.

Side Effects: Note: Side effects listed are those with a frequency of 0.1% or greater. CV: Hypotension, vasodilation, postural hypotension, syncope, migraine, arrhythmia. GI: Hepatotoxicity, dry mouth, constipation, pharyngitis, vomiting, abdominal pain, diarrhea, dyspepsia, dysphagia, cholelithiasis, fecal impaction, flatulence, GI hemorrhage hepatitis, melena. CNS: Dizziness, dyskinesia, nervousness, somnolence, sedation, hallucinations, psychotic-like symptoms, depression, anxiety, paresthesia, tremor, emotional lability, seizures, paralysis, abnormal thinking, vertigo, abnormal dreams, agitation, depersonalization, euphoria, stupor, dysautonomia, neuralgia. GU: Urinary frequency, UTI, urinary urgency, cystitis, menorrhagia, pyelonephritis, urinary retention, kidney calculus, enlarged uterine fibroids, vaginal moniliasis, vaginitis. Hematologic: Ecchymosis, anemia, leukopenia, leukocytosis. Musculoskeletal: Myasthenia, back pain, pathological fracture, arthralgia, arthritis, bursitis. Respiratory: Sinusitis, pneumonia, bronchitis, rhinitis. Dermatologic: Rash, sweating, skin ulcer, pruritus, dry skin, acne, alopecia, urticaria. Body as a whole: Flu syndrome, weight loss, infection, sepsis, cellulitis, death allergic reaction, moniliasis, malaise, asthenia, fever, abscess, edema. Ophthalmic: Glaucoma, amblyopia, conjunctivitis, eye pain, optic neuritis, retinal hemorrhage, visual field defect. Otic: Ear pain, tinnitus, deafness, otitis media. Miscellaneous: Speech disorder.

Laboratory Test Alterations: ALT. Abnormal LFTs. Hypercholesterolemia, hyperlipemia, hypothyroidism, adrenal cortical insufficiency, hyperglycemia, hypokalemia, hyponatremia, hypoproteinemia.

Drug Interactions: Alcohol / Tizanidine side effects; additive CNS depressant effects Alpha-2-adrenergic agonists / Additive hypotension Oral contraceptives / Tizanidine clearance

How Supplied: Tablets: 4 mg

?Tablets Muscle spasticity.
Initial: 4 mg; then increase dose gradually in 2 to 4 mg steps to optimum effect. Dose can be repeated at 6-8-hr intervals, to maximum of 3 doses/24 hr, not to exceed 36 mg/day. There is no experience with repeated, single, daytime doses greater than 12 mg or total daily doses of 36 mg or more.

Tizanidine hydrochloride Ratings

Overall Rating:



(based on 2 reviews)



Ease of Use:


Overall Satisfaction:




Tizanidine hydrochloride

Effectiveness: ****

Ease of Use: **

Overall Satisfaction: *


Lisa Bristow, Texarkana, texas - 06/04/2014

Okay sure it takes out the "o my GODpain"........Im a mom of three on pain mmanagnent...I can inly taje in 3 mins before bed ...it kicks in very fast vbasicly it over foes it self....isnt there a medium ? And I had xanafkex niw it went from white pills to hci vapsul...what make hci .what is HCI ???

Tizanidine hydrochloride

Effectiveness: *

Ease of Use: *

Overall Satisfaction: *


Ripplelina, Alaska - 07/06/2011

Does not answer the question whether tizanidine shows up in a urine test or not!

2 comments | Reply


Seri, Seri - 01/13/2014

use appropriate tab or cap srtnegth. After a 30 minute on the telephone the Pharmacist still wasn't certain what the message meant.I took out my cell phone and called Humana. The message meant Quantity Limitations. Humana decided my daughter should get 90 tabs over a 30 day period. I asked why? I was told that Humana uses a Pharmacy Review Board to set the dosages for medications based upon recommendations by the FDA and Drug Manufacturer.The next day I called the FDA and Janssen Pharmaceuticals. Both of them disagreed with Humana over the phone and with a PDF document on their website. There are multiple conditions treated by Topamax, we don't recommend 25 mg three times a day for any condition. We recommend you FOLLOW YOUR DOCTORS ADVICE.I called Humana repeatedly. I didn't care about the usage limits. They are in business to make money. Don't lie to me. Just tell me you are using quantity limits to save money. But they stuck to their guns, and tell me it is for the best of the patient. Good thing I have such a good physician.


Amber, Amber - 03/06/2014

Once your relevant class is determined, the QuotesChimp looks even more deeply into the statistics. Based on the class involved and the type of insurance being sought, the insurance company will determine what the average expectancy of loss will be within the class. For example, in a given community, five houses may be expected to burn per year. This information is important in setting prices, as we shall soon see.