Questions | Reviews
have leg pain called restless leg sydome. Is this tizanidine right for this pain?? I have taken requip but it doesent help
by Josephine B in West Virgunia, 05/08/2006
Hey! I was wondering does Tizanidine hydrochloride (zanaflex) show up on a drug test? And if it does , what does it show up as? I was wondering because I have random drug testing for my job & my doc gave me these for migraines. well than...
by Carrie in Birmingham , Al., 07/07/2007
I've been taking Tizanidine for muscle spasms in my neck. I have MS and I feel my appetite has increased 180% yet, i do not see that as a side effect. Has anyone ever had this happen? I think I'm stopping tonight, I can't stand what my bod...
by Jodie in Pittsfield, MA, 05/30/2007
I'm applying job a job that requires drug testing and im on this medication tizanidine hcl 4mg,how would it show up on the test false positive or negative. my appointment is 1-2-07 .if you could get back on me with this i would greatly appreciate ...
by darlene in us, 12/29/2006
Classification: Skeletal muscle relaxant, centrally-acting
See Also: See also Skeletal Muscle Relaxants, Centrally Acting.
Action/Kinetics: Acts on central þ-2 adrenergic receptors; reduces spasticity by increasing presynaptic inhibition of motor neurons possibly by reducing release of excitatory amino acids. Greatest effects are on polysynaptic pathways. Also may reduce postsynaptic excitatory transmitter activity, decrease the firing rate of noradrenergic locus ceruleas neurons, and inhibit synaptic transmission of nociceptive stimuli in the spinal pathways. Peak effect: 1-2 hr. Duration: 3-6 hr. Extensive first pass metabolism. t 1/2: About 2.5 hr. Excreted in urine and feces. Elderly clear drug more slowly.
Uses: Acute and intermittent management of muscle spasticity.
Contraindications: Use with þ-2-adrenergic agonists.
Special Concerns: Use with caution in renal impairment, in elderly and during laction. Use with extreme caution in hepatic insufficiency. Safety and efficacy have not been determined in children.
Side Effects: Note: Side effects listed are those with a frequency of 0.1% or greater. CV: Hypotension, vasodilation, postural hypotension, syncope, migraine, arrhythmia. GI: Hepatotoxicity, dry mouth, constipation, pharyngitis, vomiting, abdominal pain, diarrhea, dyspepsia, dysphagia, cholelithiasis, fecal impaction, flatulence, GI hemorrhage hepatitis, melena. CNS: Dizziness, dyskinesia, nervousness, somnolence, sedation, hallucinations, psychotic-like symptoms, depression, anxiety, paresthesia, tremor, emotional lability, seizures, paralysis, abnormal thinking, vertigo, abnormal dreams, agitation, depersonalization, euphoria, stupor, dysautonomia, neuralgia. GU: Urinary frequency, UTI, urinary urgency, cystitis, menorrhagia, pyelonephritis, urinary retention, kidney calculus, enlarged uterine fibroids, vaginal moniliasis, vaginitis. Hematologic: Ecchymosis, anemia, leukopenia, leukocytosis. Musculoskeletal: Myasthenia, back pain, pathological fracture, arthralgia, arthritis, bursitis. Respiratory: Sinusitis, pneumonia, bronchitis, rhinitis. Dermatologic: Rash, sweating, skin ulcer, pruritus, dry skin, acne, alopecia, urticaria. Body as a whole: Flu syndrome, weight loss, infection, sepsis, cellulitis, death allergic reaction, moniliasis, malaise, asthenia, fever, abscess, edema. Ophthalmic: Glaucoma, amblyopia, conjunctivitis, eye pain, optic neuritis, retinal hemorrhage, visual field defect. Otic: Ear pain, tinnitus, deafness, otitis media. Miscellaneous: Speech disorder.
Laboratory Test Alterations: ALT. Abnormal LFTs. Hypercholesterolemia, hyperlipemia, hypothyroidism, adrenal cortical insufficiency, hyperglycemia, hypokalemia, hyponatremia, hypoproteinemia.
How Supplied: Tablets: 4 mg