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Tetracycline hydrochloride
Tetracycline hydrochloride (Achromycin Ophthalmic Ointment, Achromycin Ophthalmic Suspension)
Tetracycline hydrochloride
(teh-trah-
SYE-kleen)
Pregnancy Category: D
Achromycin Ophthalmic Ointment
Achromycin Ophthalmic Suspension
Actisite Periodontal Fiber
Apo-Tetra
Jaa Tetra
Nor-Tet
Novo-Tetra
Nu-Tetra
Panmycin
Robicaps
Sumycin 250 and 500
Sumycin Syrup
Tetracap
Tetracyn
Topicycline Topical Solution
(Rx)
Classification:
Antibiotic, tetracycline
See Also:
See also
Tetracyclines
[.
]
Action/Kinetics:
t
1/2: 7-11 hr. From 40% to 70% excreted unchanged in urine; 65% bound to serum proteins. Always express dose as the hydrochloride salt.
Additional Uses:
PO: As part of combination therapy to eradicate
H. pylori infections.
Ophthalmic: Superficial ophthalmic infections due to
Staphylococcus aureus, Streptococcus, Streptococcus pneumoniae, Escherichia coli, Neisseria and
Bacteroides. Prophylaxis of
Neisseria gonorrhoeae in newborns. With oral therapy for treatment of
Chlamydia trachomatis.
Topical: Acne vulgaris, prophylaxis or treatment of infection following skin abrasions, minor cuts, wounds, or burns.
Tetracycline fiber: Adult periodontitis.
Investigational: Pleural sclerosing agent in malignant pleural effusions (administered by chest tube); in combination with gentamicin for
Vibrio vulnificus infections due to wound infection after trauma or by eating contaminated seafood. Mouthwash (use suspension) to treat nonspecific mouth ulcerations, canker sores, aphthous ulcers. Possible drug of choice for stage I Lyme disease.
Contraindications:
Use of the topical ointment in or around the eyes. Ophthalmic products to treat fungal diseases of the eye, dendritic keratitis, vaccinia, varicella, mycobacterial eye infections, or following removal of a corneal foreign body.
Special Concerns:
Use tetracycline fiber with caution in clients with a history of oral candidiasis. Use of the fiber in chronic abscesses has not been evaluated. Safety and efficacy of the fiber have not been determined in children.
Additional Side Effects:
Temporary blurring of vision or stinging following administration. Dermatitis and photosensitivity following ophthalmic use.
Use of the tetracycline fiber: Oral candidiasis, glossitis, staining of the tongue, severe gingival hyperplasia, minor throat irritation, pain following placement in an abscessed area, throbbing pain, hypersensitivity reactions.
How Supplied:
Tetracycline:
Syrup: 125 mg/5 mL;
Tetracycline hydrochloride:
Capsule: 100 mg, 250 mg, 500 mg;
Ointment: 3%;
Tablet: 250 mg, 500 mg
Dosage
?Capsules, Syrup, Tablets
Mild to moderate infections.
Adults, usual: 500 mg b.i.d. or 250 mg q.i.d.
Severe infections.
Adult: 500 mg q.i.d.
Children over 8 years: 25-50 mg/kg/day in four equal doses.
Eradication of
H. pylori.
The following regimens may be used: (1) Tetracycline, 500 mg q.i.d. for 2 weeks, plus metronidazoloe, 250 mg q.i.d. for 2 weeks, plus bismsuth subsalicylate, 525 mg q.i.d. for 2 weeks, plus a H2 receptor antagonist. (2) Clarithromycin, 500 mg b.i.d. for 2 weeks, plus ranitidine bismuth citrate, 400 mg b.i.d. for 4 weeks, plus either metronidazole, 500 mg b.i.d., or amoxicillin, 1 g b.i.d., or tetracycline, 500 mg b.i.d. for 2 weeks. (3) Tetracycline, 500 mg q.i.d. for 2 weeks, plus metronidazole, 500 mg t.i.d. for 2 weeks, plus bismuth subsalicylate, 525 mg q.i.d. for 2 weeks, plus either lansoprazole, 30 mg once daily or omeprazole, 20 mg once daily, for 2 weeks.
Brucellosis.
500 mg q.i.d. for 3 weeks with 1 g streptomycin IM b.i.d. for first week and once daily the second week.
Syphilis.
Total of 30-40 g over 10-15 days.
Gonorrhea.
Initially, 1.5 g;
then, 500 mg q 6 hr until 9 g has been given.
Gonorrhea sensitive to penicillin.
Initially, 1.5 g;
then, 500 mg q 6 hr for 4 days (total: 9 g).
NOTE: The CDC have established treatment schedules for STDs.
GU or rectal
Chlamydia trachomatis
infections.
500 mg q.i.d. for minimum of 7 days.
Severe acne.
Initially, 1 g/day;
then, 125-500 mg/day (long-term).
?Topical
Acne.
Apply topical solution to affected areas in the morning and at night, making sure that skin is completely wet after each application.
Infections.
Apply OTC ointment (3%) to affected areas 1-4 times/day. A sterile bandage may be used.
?Tetracycline Fiber
Adult periodontitis.
Place the fiber into the periodontal pocket until the pocket is filled (amount of fiber will vary with pocket depth and contour) ensuring that the fiber is in contact with the base of the pocket. Retain the fiber in place for 10 days, after which it is to be removed. The effectiveness of subsequent therapy with the fiber has not been assessed. |
