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Suprofen (Profenal)
(sue- PROH-fen)
Pregnancy Category: C Profenal (Rx)

Classification: Nonsteroidal anti-inflammatory drug, ophthalmic use

See Also: See also Nonsteroidal Anti-Inflammatory Drugs .

Action/Kinetics: By inhibiting prostaglandin synthesis, suprofen reverses prostaglandin-induced vasodilation, leukocytosis, increased vascular permeability, and increased intraocular pressure. Also inhibits miosis, which occurs during cataract surgery.

Uses: Inhibition of intraoperative miosis.

Contraindications: Dendritic keratitis.

Special Concerns: Use with caution during lactation, in clients sensitive to aspirin and other NSAIDs, and in surgical clients with a history of bleeding tendencies or who are on drugs that prolong bleeding time. Safety and efficacy have not been established in children.

Side Effects: Ophthalmic: Ocular irritation, transient burning, and stinging on installation. Redness, itching, discomfort, pain, iritis, allergy, chemosis, photophobia, punctate epithelial staining.

Drug Interactions: Acetylcholine and carbachol may be ineffective if used in combination with suprofen.

How Supplied: Solution: 1%

?Ophthalmic Solution Day before surgery.
2 gtt into the conjunctival sac q 4 hr during waking hours.
Day of surgery.
2 gtt into the conjunctival sac 3, 2, and 1 hr prior to surgery.

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