Sotalol hydrochloride Dosage, Interactions, Side Effects, How to Use

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glycemic effect (ability of sotalol hydrochloride to raise blood sugar level) Can taking 80 mg of sotalol hydrochloride 1 1/2 tablets twice a day increase my blood sugar? by Richard Nielson in South Bend, IN, U.S.A., 12/02/2005

Reducing my dosage of Sotalol Hydrchloride I was diagnosed with Supraventricular Tachycardia 11 years ago and have been taking Sotalol beta blockers ever since. I was started on 40mg but the attacks were still happening so was put on 80mgs twice a day. I have always felt tired and sluggish on ... by Mary Slater in St Leonards on Sea, 02/22/2008

ALCOHOL mixing with Sotalol hydrochloride? AM i ALLOWED TO HAVE A GLASS OF WINE WITH MY EVENING MEAL,AT PRESENT I AM ON 40MG TWICE DAILY. by ANN SCONCE in CHESTER ENGLAND, 02/15/2007

side affects of sotalol hydrochloride Can a dosage of 40mg. twice a day cause joint paints, especially in lower arms and thumbs? Have been taking this drug now for about three weeks in addition to warfarin and digoxin. by Mrs J.L. Jones in U.K., 07/30/2006

Would certain foods effect Sotalol Hydrochloride- especially grapefruit I use Sotalol as a Beta Blocker. I have recently had a reaction, I think from eating grapefruit immediately after taking Sotalol. Could the grapefruit effect the drug? by Jim Shipp in United Kingdom, 05/20/2006

Sotalol hydrochloride
Sotalol hydrochloride (Betapace)
Sotalol hydrochloride
( SOH-tah-lol)
Pregnancy Category: B Alti-Sotalol Apo-Sotalol Betapace Gen-Sotalol Linsotalol Novo-Sotalol Nu-Sotalol Rylosol Sotacor (Rx)

Classification: Beta-adrenergic blocking agent

See Also: See also Beta-Adrenergic Blocking Agents .

Action/Kinetics: Blocks both beta-1- and beta-2-adrenergic receptors; has no membrane-stabilizing activity or intrinsic sympathomimetic activity. Has both Group II and Group III antiarrhythmic properties (dose dependent). Significantly increases the refractory period of the atria, His-Purkinje fibers, and ventricles. Also prolongs the QTc and JT intervals. t 1/2: 12 hr. Not metabolized; excreted unchanged in the urine.

Uses: Treatment of documented ventricular arrhythmias such as life-threatening sustained VT. Reduction and delay in incidence of atrial fibrillation/flutter in those with normal sinus rhythm who have a recent history of atrial fibrillation/flutter that causes severe or disabling symptoms.

Contraindications: Use in asymptomatic PVCs or supraventricular arrhythmias due to the proarrhythmic effects of sotalol. Congenital or acquired long QT syndromes. Use in clients with hypokalemia or hypomagnesemia until the imbalance is corrected, as these conditions aggravate the degree of QT prolongation and increase the risk for torsades de pointes.

Special Concerns: Clients with sustained ventricular tachycardia and a history of CHF appear to be at the highest risk for serious proarrhythmia. Dose, presence of sustained ventricular tachycardia, females, excessive prolongation of the QTc interval, and history of cardiomegaly or CHF are risk factors for torsades de pointes. Use with caution in clients with chronic bronchitis or emphysema and in asthma if an IV agent is required. Use with extreme caution in clients with sick sinus syndrome associated with symptomatic arrhythmias due to the increased risk of sinus bradycardia, sinus pauses, or sinus arrest. Reduce dosage in impaired renal function. Safety and efficacy in children have not been established.

Additional Side Effects: CV: New or worsened ventricular arrhythmias, including sustained VT or ventricular fibrillation that might be fatal. Torsades de pointes.

How Supplied: Tablet: 80 mg, 120 mg, 160 mg, 240 mg

Dosage
?Tablets Ventricular arrhythmias.
Adults, initial: 80 mg b.i.d. The dose may be increased to 240 or 320 mg/day after appropriate evaluation. Usual: 160-320 mg/day given in two or three divided doses. Clients with life-threatening refractory ventricular arrhythmias may require doses ranging from 480 to 640 mg/day (due to potential proarrhythmias, use these doses only if the potential benefit outweighs the increased risk of side effects).