Sibutramine hydrochloride monohydrate


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Tingling/Painful sensations in fingers: possible side effect of Reductil 15mg


Dear Sir or Madam: I am a 31 yrs old female, married with 3 kids (5-yr, 4-yr, 20mths). Suffering with depression from the start of my marriage for past 7 years. Took last year Cipralex for 6 mths to treat depression & my comfort eating due to depr...
by Anonymous in Manama, Bahrain, 08/24/2006

Why do i still feel hungry after 6 weeks of sibutramine?


I have been using sibutramine capsules for 6 weeks and still feel hungry. what am i doing wrong?
by Hayley Ashcroft in united kingdom, 11/29/2005

Sibutramine hydrochloride monohydrate


I would like to know if there are any long-term side effects when using this medication used for losing weight, in case of future pregnancy or any other sort of illnesses that are possible to occur. Awaiting your reply. Thank you
by Misha Abdullah in Dhahran, Saudi Arabia, 11/18/2005

Sibutramine hydrochloride monohydrate
Sibutramine hydrochloride monohydrate (Meridia)
Sibutramine hydrochloride monohydrate
(sih- BYOU-trah-meen)
Pregnancy Category: C Meridia (Rx) (C-IV)

Classification: Anti-obesity drug

Action/Kinetics: Main effect is likely due to primary and secondary amine metabolites of sibutramine. Inhibits reuptake of norepinephrine (NE) and serotonin (5HT), resulting in enhanced NE and 5HT activity and reduced food intake. Significant improvement in serum uric acid. Rapidly absorbed from GI tract. Extensive first-pass metabolism in liver. Peak plasma levels of active metabolites: 3-4 hr. t 1/2, sibutramine: 1.1 hr; t 1/2, active metabolites: 14-16 hr. Excreted in urine and feces.

Uses: Management of obesity, including weight loss and maintenance of weight loss. Recommended for obese clients with initial body mass index of 30 kg/m 2 or more or 27 kg/m 2 in presence of hypertension, diabetes, or dyslipidemia. Use in conjunction with reduced calorie diet. Safety and efficacy have not been determined for more than 1 year.

Contraindications: Lactation. Use in clients receiving MAO inhibitors, who have anorexia nervosa, those taking centrally-acting appetite suppressant drugs, those with history of coronary artery disease, CHF, arrhythmias, or stroke. Use in severe renal impairment or hepatic dysfunction. Use with serotonergic drugs, such as fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, sumatriptan, and dihydroergotamine; also, use with dextromethorphan, meperidine, pentazocine, fentanyl, lithium, or tryptophan.

Special Concerns: Use with caution in geriatric clients. Safety and efficacy have not been determined in children less than 16 years of age. Use with caution in narrow angle glaucoma, history of seizures, or with drugs that may raise BP (e.g., phenylpropanolamine, ephedrine, pseudoephedrine). Exclude organic causes (e.g., untreated hypothyroidism) before use.

Side Effects: Body as a whole: Headache, back pain, flu syndrome, injury/accident, asthenia, chest pain, neck pain, allergic reaction. GI: Dry mouth, anorexia, abdominal pain, constipation, N&V, rectal disorder, increased appetite, dyspepsia, gastritis. CNS: Insomnia, dizziness, paresthesia, nervousness, anxiety, depression, somnolence, CNS stimulation, emotional lability. CV: Increased blood pressure, tachycardia, vasodilation, migraine, palpitation. Dermatologic: Sweating, rash, herpes simplex, acne. Musculoskeletal: Arthralgia, myalgia, tenosynovitis, joint disorder. Respiratory: Rhinitis, pharyngitis, sinusitis, increase cough, laryngitis. GU: Dysmenorrhea, UTI, vaginal monilia, metrorrhagia. Otic: Ear disorder, ear pain. Miscellaneous: Thirst, generalized edema, taste perversion.

How Supplied: Capsules: 5 mg, 10 mg, 15 mg

Dosage
?Capsules Obesity.
Adults, initial: 10 mg once daily (usually in morning) with or without food. If there is inadequate weight loss, dose may be titrated after 4 weeks to total of 15 mg once daily. Do not exceed 15 mg daily.

Sibutramine hydrochloride monohydrate Ratings

Overall Rating:

3.5***~

 

(based on 5 reviews)

Effectiveness:

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Ease of Use:

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Overall Satisfaction:

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Reviews

Sibutramine hydrochloride monohydrate
5.0

Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****

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Garry Spriggs, brooklyn ny - 08/14/2008

I take 10 milligrams of Meridia each day, and, combined with more exercise and a better diet, it has worked very well for me. I actually lost over 120 pounds in a year and a half, from November of 2008 to March of 2010. With Meridia, I have been able to maintain my target weight of 175 pounds since last march. However, right now my doctor is reducing my dose gradually so I will not have to take it anymore. I have not experienced any extra weight gain or been more hungry on the days that I don't take the medication. Actually, I have not had a single negative side effect with the medicine at all. Taking it has improved my perspective on life and given me more energy and a higher libido. I really can't praise it enough. I am a 63 year old man whose life has truly been changed by taking Meridia.

Sibutramine hydrochloride monohydrate
5.0

Effectiveness: *****

Ease of Use: *****

Overall Satisfaction: *****

Avatar_thumbnail

renae delp, Wisconsin - 12/02/2008

Meridia will absolutely help in the weight loss department. It did for me. I lost more than 60 lbs. in less than one year. How many people can say they did that? The reason I went on the medication is because I was in my mid-fifties and didn't want to have to worry about diabetes II. Since that time, I have learned that staying on for about two years is the best approach. Even better is that when you take Meridia, you don't think about food all the time. You focus on things you need to get done instead. A little weight will come back after a while, but nothing like prior to taking the medication.