Pyridoxine hydrochloride


Questions | Reviews

Alchohol Properties


Would it be possible for a drink with hydrochloride to make a alchohol test register at all if it were drank right before the test. (Pomegranite Rockstar)
by Duanne Travis in New York, 11/05/2007

use of pyridoxine to prevent hand foot syndrome caused by oral chemotherapy


Can Pyridoxine be used to prevent or lessen the effects of hand foot syndrome in chemotherapy patients. Several different chemotherapy agents cause hand foot syndrome as a side effect and there have been suggestions that pyridoxine might decrease thos...
by Michele Dickison in Moscow, ID, 02/27/2006

Is it a Vitamin Tablet


Could you please let me know what are the advantages and side affects of Paridoxine Hydrocloride.  Is it a Vitamin Tablet or for some disease.  Thanks, Praveen  
by Praveen in Mangalore,India, 09/07/2006

Pyridoxine hydrochloride
(Vitamin B 6)

Pyridoxine hydrochloride (Vitamin B 6)
Vitamin B 6 Nestrex
Pyridoxine hydrochloride
(peer-ih- DOX-een)
Pregnancy Category: A (C for doses that exceed the RDA) Aminoxin Nestrex (Rx: Injection; OTC: Tablets)

Classification: Vitamin B complex

Action/Kinetics: A water-soluble, heat-resistant vitamin that is destroyed by light. Acts as a coenzyme in the metabolism of protein, carbohydrates, and fat. As the amount of protein increases in the diet, the pyridoxine requirement increases. However, pyridoxine deficiency alone is rare. t 1/2: 2-3 weeks. Metabolized in the liver and excreted through the urine.

Uses: Pyridoxine deficiency including poor diet, drug-induced (e.g., oral contraceptives, isoniazid), and inborn errors of metabolism. Investigational: Hydrazine poisoning, PMS, high urine oxalate levels, N&V due to pregnancy, carpal tunnel syndrome, tardive dyskinesia due to antipsychotic drugs.

Special Concerns: Safety and effectiveness have not been established in children for doses that exceed the RDA.

Side Effects: CNS: Unstable gait; decreased sensation to touch, temperature, and vibration; paresthesia, sleepiness; numbness of feet; awkwardness of hands; perioral numbness, photoallergic reaction, ataxia. NOTE: Abuse and dependence have been noted in adults administered 200 mg/day.

Overdose Management: Symptoms: Ataxia, severe sensory neuropathy. Treatment: Discontinue pyridoxine; allow up to 6 months for CNS sensation to return.

Drug Interactions: Chloramphenicol / Pyridoxine requirements Contraceptives, oral / Pyridoxine requirements Cycloserine / Pyridoxine requirements Ethionamide / Pyridoxine requirements Hydralazine / Pyridoxine requirements Immunosuppressants / Pyridoxine requirements Isoniazid / Pyridoxine requirements Levodopa / Doses exceeding 5 mg/day pyridoxine antagonize the therapeutic effect of levodopa Penicillamine / Pyridoxine requirements Phenobarbital / Serum phenobarbital levels Phenytoin / Serum phenytoin levels

How Supplied: Enteric coated tablet: 20 mg; Injection: 100 mg/mL; Tablet: 25 mg, 50 mg, 100 mg, 250 mg, 500 mg; Tablet, extended release: 200 mg

Dosage
?Enteric-Coated Tablets, Tablets RDAs.
The RDAs are as follows: Adult males: 1.7-2 mg. Adult females: 1.4-1.6 mg.
Dietary supplement.
Adults: 10-20 mg/day for 2 weeks; then, 2-5 mg/day as part of a multivitamin preparation for several weeks. Pediatric, 2.5-10 mg/day for 3 weeks; then, 2-5 mg/day as part of a multivitamin preparation for several weeks.
Drug-induced deficiency.
Adults, prophylaxis: 6-100 mg/day for isoniazid. Adults, treatment: 50-200 mg/day for 3 weeks followed by 25-100 mg/day to prevent relapse. Adults, alcoholism: 50 mg/day for 2-4 weeks; if anemia responds, continue pyridoxine indefinitely.
?IM, IV Drug-induced deficiency.
Adults: 50-200 mg/day for 3 weeks followed by 25-100 mg/day as needed.
Cycloserine poisoning.
Adults: 300 mg/day.
Isoniazid poisoning.
Adults: 1 g for each gram of isoniazid taken.

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