Praziquantel Dosage, Interactions, Side Effects, How to Use

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Praziquantel Dosage I have purchased Paziquantel for my adult cat ... (3) 23 mg tablets. The directions do not say how much to give my cat at what intervals. Can you please tell me that? Is it one tab a day for three days? Is it all three tabs at once? Or just one tablet... by Lora Amara in California USA, 08/07/2006

Praziquantel dosage for a 8-9 month old cat about 5 lbs I have a 8 to 9 month old kitten who has tapeworms. How much of a dosage should she be given? They are 23mg pills. I have previously given her 1/2 of one 23mg pill about 2 1/2 months ago. Thanks for your help, Kelley by Kelley, 12/05/2005

dosage of praziquantel for an adult dog for removal of tapeworms, thanks I have two adult dogs, one weighing 35lbs and one weighing 90lbs. They both have Tapeworms. I need to know the dosage of praziquantel, to give each dog and how many times I need to do this. thanks. Lona Gharst by Lona Gharst in Augusta, Montana 59410, 01/15/2007

Praziquantel
Praziquantel (Biltricide)
Praziquantel
(pray-zih- KWON-tell)
Pregnancy Category: B Biltricide (Rx)

Classification: Anthelmintic

Action/Kinetics: Causes increased cell permeability in the helminth, resulting in a loss of intracellular calcium with massive contractions, and paralysis of musculature with breakdown of the integrity of the organism. Also causes vacuolization and disintegration of phagocytes to the parasite, resulting in death. Maximum serum levels: 1-3 hr. t 1/2: 0.8-1.5 hr. Levels in the CSF are approximately 14%-20% of the total amount of the drug in the plasma. Significant first-pass effect. Excreted primarily in the urine.

Uses: Schistosomal infections due to Schistosoma japonicum, S. mansoni, S. mekongi and S. hematobium. Liver flukes ( Clonorchis sinensis, Opisthorchis viverrini). Investigational: Neurocysticercosis, other tissue flukes, and intestinal cestodes. Low doses of oxamniquine and praziquantel as a single-dose treatment of schistosomiasis.

Contraindications: Ocular cysticercosis. Lactation.

Special Concerns: Safety in children less than 4 years of age not established.

Side Effects: GI: Nausea, abdominal discomfort. CNS: Malaise, headache, dizziness, drowsiness. Miscellaneous: Fever, urticaria (rare). NOTE: These side effects may also be due to the helminth infection itself.

Overdose Management: Symptoms: Extension of side effects. Treatment: Administer a fast-acting laxative.

Drug Interactions: Hydantoins may decrease serum praziquantel levels, resulting in ineffective treatment.

How Supplied: Tablet: 600 mg

Dosage
?Tablets Schistosomiasis.
Three doses of 20 mg/kg as a 1-day treatment with an interval between doses not less than 4 hr or more than 6 hr.
Chonorchiasis and opisthorchiasis.
Three doses of 25 mg/kg as a 1-day treatment with an interval between doses not less than 4 hr or more than 6 hr.