Pramipexole


Questions | Reviews **~

Pramipexole dosage


My neurologist recently noted I should increase my mirapexin from 2 tablets 3 times a day to 3 tablets 3 times a day for a week, then 4 tablets 3 times a day. I was on 0.18 mg and I have the impression he thought I was on 0.088 mg. In his letter the n...
by J Salad in London England, 05/19/2006

Pramipexole
Pramipexole (Mirapex)
Pramipexole
(prah-mih- PEX-ohl)
Pregnancy Category: C Mirapex (Rx)

Classification: Antiparkinson drug

Action/Kinetics: Thought to act by stimulating dopamine (especially D 3) receptors in striatum. Rapidly absorbed. Peak levels: 2 hr. Food increases time for maximum levels to occur. t 1/2, terminal: About 8 hr (12 hr in geriatric clients). Excreted mainly unchanged in urine. Clearance decreases with age.

Uses: Idiopathic Parkinson's disease.

Contraindications: Lactation.

Special Concerns: Possible sudden, overwhelming urge to sleep. Safety and efficacy have not been determined in children.

Side Effects: CNS: Hallucinations (especially in elderly), dizziness, somnolence, insomnia, confusion, amnesia, hypesthesia, dystonia, akathisia, abnormal thinking, decreased libido, myoclonus. CV: Orthostatic hypotension. Body as a whole: Asthenia, general edema, malaise, fever. GI: Nausea, constipation, anorexia, dysphagia. Miscellaneous: Vision abnormalities, impotence, peripheral edema, decreased weight.

Drug Interactions: Butyrophenones / Possible effect of pramipexole Cimetidine / Levodopa levels and half-life CNS Depressants / Additive CNS depression Levodopa / Levodopa levels; also, may cause or worsen pre-existing dyskinesia Metoclopramide / Possible effect of pramipexole Phenothiazines / Possible effect of pramipexole Thioxanthines / Possible effect of pramipexole

How Supplied: Tablets: 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, 1.5 mg

Dosage
?Tablets Parkinsonism.
Initial: Start with 0.125 mg t.i.d.; then increase dose by 0.125 mg t.i.d. weekly for seven weeks (i.e., dose at week seven is 1.5 mg t.i.d.). Maintenance: 1.5-4.5 mg/day in equally divided doses t.i.d. with or without comcomitant levodopa (about 800 mg/day). Impaired renal function, C CR, over 60 mL/min: Start with 0.125 mg t.i.d., up to maximum of 1.5 mg t.i.d. C CR, 25-59 mL/min: Start with 0.125 mg b.i.d., up to maximum of 1.5 mg b.i.d. C CR, 15-24 mL/min: Start with 0.125 mg once daily, up to maximum of 1.5 mg once daily.

Pramipexole Ratings

Overall Rating:

2.5**~

 

(based on 2 reviews)

Effectiveness:

***

Ease of Use:

**~

Overall Satisfaction:

**~

Reviewit

Reviews

Pramipexole
3.5

Effectiveness: **

Ease of Use: ****

Overall Satisfaction: ****

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Rizky, Rizky - 01/13/2014

I wish I could offer you some suggestions, but all I can do is corifnm your experiences. Mirapex is known to cause compulsive behavior gambling, shopping, sexual, etc. I hope that the drug companies, doctors, and pharmacists take this seriously and help those of us on this drug. I've heard the withdrawl is awful. (sorry, I'm full of bad news) Please also note that antidepressants can cause PD or RLS symptoms to worsen drugs such as Willbutrin. Zoloft also causes weight gain. I'm trying more vitamins (B, D and Calcium), as well as iron supplements, watching what I eat and drink close to bedtime, no sugar, cinnamon, caffiene, etc Trying more natural relief although I am still taking Mirapex at night for my RLS. It would be great to get off of it. Perhaps more people will find this post and eventually we will get some help. Let's stick together and not lose hope!Jenna