Pirbuterol acetate

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Pirbuterol acetate
Pirbuterol acetate (Maxair Autohaler)
Pirbuterol acetate
(peer- BYOU-ter-ohl)
Pregnancy Category: C Maxair Autohaler Maxair Inhaler (Rx)

Classification: Sympathomimetic, bronchodilator

See Also: See also Sympathomimetic Drugs .

Action/Kinetics: Causes bronchodilation by stimulating beta-2-adrenergic receptors. Has minimal effects on beta-1 receptors. Also inhibits histamine release from mast cells, causes vasodilation, and increases ciliary motility. Onset, inhalation: Approximately 5 min. Time to peak effect: 30-60 min. Duration: 5 hr.

Uses: Alone or with theophylline or steroids for prophylaxis and treatment of bronchospasm in asthma and other conditions with reversible bronchospasms (e.g., exercise-induced bronchospasm), including bronchitis, emphysema, bronchiectasis, obstructive pulmonary disease.

Contraindications: Cardiac arrhythmias due to tachycardia; tachycardia caused by digitalis toxicity.

Special Concerns: Safety and efficacy have not been determined in children less than 12 years of age.

Additional Side Effects: CV: PVCs, hypotension. CNS: Hyperactivity, hyperkinesia, anxiety, confusion, depression, fatigue, syncope. GI: Diarrhea, dry mouth, anorexia, loss of appetite, bad taste or taste change, abdominal pain, abdominal cramps, stomatitis, glossitis. Dermatologic: Rash, edema, pruritus, alopecia. Miscellaneous: Flushing, numbness in extremities, weight gain.

How Supplied: Autohaler or Inhaler: 0.2 mg/inh

?Inhalation Aerosol Bronchodilation.
Adults and children over 12 years: 0.2-0.4 mg (1-2 inhalations) q 4-6 hr, not to exceed 12 inhalations (2.4 mg) daily.

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