Pipobroman


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Pipobroman
Pipobroman Vercyte
Pipobroman
(pip-oh- BROH-man)
Pregnancy Category: D

Classification: Antineoplastic, alkylating agent.

See Also: See also Antineoplastic Agents and Alkylating Agents .

Action/Kinetics: The mechanism, metabolism, and excretion are not known. Well absorbed from the GI tract.

Uses: Polycythemia vera; chronic granulocytic leukemia in clients refractory to busulfan.

Additional Contraindications: Children under 15 years of age. Lactation. Bone marrow depression due to chemotherapy or X rays.

Special Concerns: Bone marrow depression may not occur for 4 or more weeks after therapy is started.

Side Effects: Hematologic: Leukopenia, anemia, thrombocytopenia. GI: N&V, diarrhea, abdominal cramps. Dermatologic: Skin rashes.

Overdose Management: Symptoms: Hematologic toxicity, especially with chronic overdosage. Treatment: Monitor hematologic status; if necessary, begin vigorous supportive treatment.

How Supplied: Tablet: 25 mg

Dosage
?Tablets Polycythemia vera.
1 mg/kg/day. Up to 1.5-3 mg/kg/day may be required in clients refractory to other treatment; do not use such doses until a dose of 1 mg/kg/day has been given for at least 30 days with no improvement. When hematocrit has been reduced to 50%-55%, maintenance dosage of 100-200 mcg/kg is instituted.
Chronic granulocytic leukemia.
Initial: 1.5-2.5 mg/kg/day; maintenance: 7-175 mg/day, to be instituted when leukocyte count approaches 10,000/mm 3.

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