Piperazine citrate Dosage, Interactions, Side Effects, How to Use

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does Piperazine citrate harm pregnant cats? my nameis sophi and i have a pregnant cat. she has been pregnant for over 5 wks already and now i see that she has worms. i was reading over some information online and i ran accross a page that mentioned that "piperazine" did not affect a c... by sophi in Texas, USA, 02/18/2007

Is Piperazine available over the counter? I would like to receive this medication as soon as possible due to the reason i been having ringworms for over two years and it just gets worst each time, it gets so bad i cant even walk straight or cant walk atall from pain suffering due to this dis... by robert f in san diego ca., 12/29/2005

possible roundworm I have two dogs and one of them is a puppy which was barely introduced to our family about 2 weeks ago. Since then I seem to see large corn looking types of chunks in my poop. I have abdominal pains, back pain, and eye irritation. I feel like there is... by Cindy in Bakersfield, CA, 12/15/2005

Piperazine citrate
Piperazine citrate
Piperazine citrate
(pie- PER-ah-zeen)
Pregnancy Category: B (Rx)

Classification: Anthelmintic

See Also: See also Anthelmintics .

Action/Kinetics: Acts to paralyze the muscles of parasites; this dislodges the parasites and promotes their elimination by peristalsis. Has little effect on larvae in tissues. Readily absorbed from the GI tract, is partially metabolized by the liver, and the remainder is excreted in urine. Rate of elimination differs among clients although it is excreted nearly unchanged in the urine within 24 hr.

Uses: Pinworm (oxyuriasis) and roundworm (ascariasis) infestations. Particularly recommended for pediatric use.

Contraindications: Impaired liver or kidney function, seizure disorders, hypersensitivity. Lactation.

Special Concerns: Safe use during pregnancy has not been established. Due to neurotoxicity, avoid prolonged, repeated, or excessive use in children.

Side Effects: Piperazine has low toxicity. GI: N&V, diarrhea, cramps. CNS: Tremors, headache, vertigo, decreased reflexes, paresthesias, seizures ataxia, chorea, memory decrement. Ophthalmologic: Nystagmus, blurred vision, cataracts, strabismus. Allergic: Urticaria, fever, skin reactions, purpura, lacrimation, rhinorrhea, arthralgia, bronchospasm cough. Miscellaneous: Muscle weakness.

Laboratory Test Alterations: False - or uric acid values.

Drug Interactions: Concomitant administration of piperazine and phenothiazines may result in an increase in extrapyramidal effects (including violent convulsions) caused by phenothiazines.

How Supplied: Tablet: 250 mg

Dosage
?Syrup, Tablets Pinworms.
Adults and children: 65 mg/kg/day as a single dose for 7 days up to a maximum daily dose of 2.5 g.
Roundworms.
Adults: One dose of 3.5 g/day for 2 consecutive days; pediatric: One dose of 75 mg/kg/day for 2 consecutive days, not to exceed 3.5 g/day. For severe infections, repeat therapy after 1 week.