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Pentosan polysulfate sodium
Pentosan polysulfate sodium (Elmiron)
Pentosan polysulfate sodium
( PEN-toh-san)
Pregnancy Category: B Elmiron (Rx)

Classification: Urinary analgesic

Action/Kinetics: Mechanism for urinary analgesic activity is not known. It appears to adhere to the bladder wall mucosal membrane and may act as a buffer to control cell permeability, thus preventing irritating solutes in the urine from reaching the cells. Also has a weak anticoagulant effect. Less than 3% of an administered dose is absorbed from the GI tract. t 1/2: 4.8 hr. Metabolized by the liver and spleen.

Uses: Relief of bladder pain or discomfort associated with interstitial cystitis.

Contraindications: Hypersensitivity to pentosan polysulfate sodium or related compounds.

Special Concerns: Use with caution during lactation, in those with hepatic insufficiency or spleen disorders, and in those who have a history of heparin-induced thrombocytopenia. Safety and efficacy have not been determined in children less than 16 years of age.

Side Effects: GI: Diarrhea, N&V, abdominal pain, dyspepsia, anorexia, colitis, constipation, esophagitis, flatulence, gastritis, mouth ulcer. CNS: Headache, severe emotional lability or depression, hyperkinesia, dizziness, insomnia. CV: Bleeding complications, including ecchymosis, epistaxis, gum hemorrhage. Hematologic: Anemia, leukopenia, thrombocytopenia. Respiratory: Dyspnea, pharyngitis, rhinitis. Dermatologic: Alopecia, rash, pruritus, urticaria, increased sweating. Ophthalmic: Amblyopia, conjunctivitis, optic neuritis, retinal hemorrhage. Miscellaneous: Hepatic toxicity, liver function abnormalities, allergic reactions, tinnitus, photosensitivity.

Laboratory Test Alterations: PTT, PT.

How Supplied: Capsule: 100 mg

?Capsules Interstitial cystitis.
100 mg t.i.d.

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