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Penicillin G benzathine, intramuscular
Penicillin G benzathine, intramuscular (Permapen)
Penicillin G benzathine, intramuscular
(pen-ih-
SILL-in,
BEN-zah-theen)
Pregnancy Category: B
Bicillin L-A
Megacillin Suspension
Permapen
(Rx)
Classification:
Antibiotic, penicillin
See Also:
See also
Anti-Infectives
[ and
Penicillins
][.
]
Action/Kinetics:
Penicillin G is neither penicillinase resistant nor acid stable. The product is a long-acting (repository) form of penicillin in an aqueous vehicle; it is administered as a sterile suspension.
Peak plasma levels: IM 0.03-0.05 unit/mL.
Uses:
Infections due to penicillin G sensitive microorganisms susceptible to low and prolonged serum levels. Mild to moderate URTI due to susceptible streptococci. Syphilis, yaws, bejel, and pinta. Prophylaxis of rheumatic fever or chorea. Follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.
Contraindications:
IV use.
Additional Drug Interactions:
Aspirin, ethacrynic acid, furosemide, indomethacin, sulfonamides, or thiazide diuretics may compete with penicillin G for renal tubular secretion
 prolongation of serum t
1/2 of penicillin
How Supplied:
Injection: 300,000 U/mL, 600,000 U/mL
Dosage
?Parenteral Suspension (IM Only)
URTI due to Group A streptococcus.
Adults: 1,200,000 units as a single dose;
older children: 900,000 units as a single dose;
children under 27 kg: 300,000-600,000 units as a single dose;
neonates: 50,000 units/kg as a single dose.
Early syphilis (primary, secondary, or latent).
Adults: 2,400,000 units as a single dose.
Children: 50,000 units/kg, up to the adult dose.
Gummas and cardiovascular syphilis.
Adults: 2,400,000 units q 7 days for 3 weeks.
Children: 50,000 units/kg, up to adult dose.
Neurosyphilis.
Adults: Aqueous penicillin G, 18,000,000-24,000,000 units IV/day for 10-14 days followed by penicillin G benzathine, 2,400,000 units IM q week for 3 weeks.
Yaws, bejel, pinta.
1,200,000 units in a single dose.
Prophylaxis of rheumatic fever and glomerulonephritis.
Following an acute attack, 1,200,000 units once a month or 600,000 units q 2 weeks. |