Paroxetine hydrochloride

Questions | Reviews ***


by BERNARD in MAURITIUS, 08/11/2009

withdrawal symptons

I have been on seroxat for approximately 3 years and have been gradually weaning myself off them,I have not taken any for 6 days now and my symptoms at the moment are; dry mouth/ feeling dizzy and disorientated//forgetful//weak as in body feels like j...
by jan moreton in england, 01/28/2008

Withdrawal regimen; side effects

How long should I stay on Paxil if I'm doing better? I worry about addiction. I have been on it for 5 months now. I tried backing it down myself by skipping a day or two, but my head feels cloudy, I have vertigo, so I went back to my normal dosage. Is...
by Paul in Sacramento, CA, 01/28/2006

Paroxetine hydrochloride
Paroxetine hydrochloride (Paxil)
Paroxetine hydrochloride
(pah- ROX-eh-teen)
Pregnancy Category: B Paxil Paxil CR (Rx)

Classification: Antidepressant

See Also: See also Selective Serotonin Reuptake Inhibitors.

Action/Kinetics: Completely absorbed from the GI tract. Time to peak plasma levels: 5.2 hr. Peak plasma levels: 61.7 ng/mL. t 1/2: 21-24 hr. Time to reach steady state: 7-14 days. Plasma levels are increased in impaired renal and hepatic function as well as in geriatric clients. Extensively metabolized in the liver to inactive metabolites. Approximately two-thirds of the drug is excreted through the urine and one-third is excreted in the feces.

Uses: Treatment of major depressive episodes, panic disorder with or without agoraphobia (as defined in DSM-IV), obsessive-compulsive disorders (as defined in DSM-IV), and social anxiety disorder (social phobia, as defined in DSM-IV). The Controlled Release is only for depression. Investigational: Headaches, diabetic neuropathy, premature ejaculation.

Additional Contraindications: Use of alcohol.

Special Concerns: Use with caution and initially at reduced dosage in elderly clients as well as in those with impaired hepatic or renal function, with a history of mania, with a history of seizures, in clients with diseases or conditions that could affect metabolism or hemodynamic responses. Concurrent administration of paroxetine with lithium or digoxin should be undertaken with caution.

Side Effects: The side effects listed were observed with a frequency up to 1 in 1,000 clients.
CNS: Headache, somnolence, insomnia, agitation, seizures tremor, anxiety, activation of mania or hypomania, dizziness, nervousness, paresthesia, drugged feeling, myoclonus, CNS stimulation, confusion, amnesia, impaired concentration, depression, emotional lability, vertigo, abnormal thinking, akinesia, alcohol abuse, ataxia, convulsions, possibility of a suicide attempt depersonalization, hallucinations, hyperkinesia, hypertonia, incoordination, lack of emotion, manic reaction, paranoid reaction. GI: Nausea, abdominal pain, diarrhea, dry mouth, vomiting, constipation, decreased appetite, flatulence, oropharynx disorder (``lump'' in throat, tightness in throat), dyspepsia, increased appetite, bruxism, dysphagia, eructation, gastritis, glossitis, increased salivation, mouth ulceration, rectal hemorrhage abnormal LFTs. Hematologic: Anemia, leukopenia, lymphadenopathy, purpura. CV: Palpitation, vasodilation, postural hypotension, hypertension, syncope, tachycardia, bradycardia, conduction abnormalities, abnormal ECG, hypotension, migraine, peripheral vascular disorder. Dermatologic: Sweating, rash, pruritus, acne, alopecia, dry skin, ecchymosis, eczema, furunculosis, urticaria. Metabolic/Nutritional: Edema, weight gain, weight loss, hyperglycemia, peripheral edema, thirst. Respiratory: Respiratory disorder (cold symptoms or URI), pharyngitis, yawn, increased cough, rhinitis, asthma, bronchitis, dyspnea, epistaxis, hyperventilation, pneumonia, respiratory flu, sinusitis. GU: Abnormal ejaculation (usually delay), erectile difficulties, sexual dysfunction, impotence, urinary frequency, urinary difficulty or hesitancy, decreased libido, anorgasmia in women, difficulty in reaching climax/orgasm in women, abortion, amenorrhea, breast pain, cystitis, dysmenorrhea, dysuria, menorrhagia, nocturia, polyuria, urethritis, urinary incontinence, urinary retention, vaginitis. Musculoskeletal: Asthenia, back pain, myopathy, myalgia, myasthenia, neck pain, arthralgia, arthritis. Ophthalmologic: Blurred vision, abnormality of accommodation, eye pain, mydriasis. Otic: Ear pain, otitis media, tinnitus. Miscellaneous: Fever, chest pain, trauma, taste perversion or loss, chills, malaise, allergic reaction, carcinoma face edema, moniliasis, anorexia.

NOTE: Over 4- to 6-week period, there was evidence of adaptation to side effects such as nausea and dizziness but less adaptation to dry mouth, somnolence, and asthenia.

Overdose Management: Symptoms: N&V, drowsiness, sinus tachycardia, dilated pupils. Treatment: Establish and maintain an airway. Ensure adequate oxygenation and ventilation. Induction of emesis, lavage, or both; following evacuation, 20-30 g activated charcoal may be given q 4-6 hr during the first 24-48 hr after ingestion. Take an ECG and monitor cardiac function if there is any evidence of abnormality. Provide supportive care with monitoring of VS.

Additional Drug Interactions Antiarrhythmics, Type IC / Possible effect R/T liver breakdown Cimetidine / Paroxetine effect R/T liver breakdown Digoxin / Possible plasma levels Phenobarbital / Possible Paroxetine effect R/T liver breakdown Phenytoin / Possible Paroxetine effect R/T liver breakdown; also, phenytoin levels Procyclidine / Procyclidine dose due to significant anticholinergic effects St. John's wort / Possible CNS depression Theophylline / Theophylline levels

How Supplied: Suspension: 10 mg/5 mL; Tablet: 10 mg, 20 mg, 30 mg, 40 mg; Tablet, Controlled Release: 12.5 mg, 25 mg

?Suspension, Tablets Depression.
Adults: 20 mg/day, usually given as a single dose in the morning. Some clients not responding to the 20-mg dose may benefit from increasing the dose in 10-mg/day increments, up to a maximum of 50 mg/day. Make dose changes at intervals of at least 1 week. Maintenance: Doses average about 30 mg/day.
Panic disorders.
Adults, initial: 10 mg/day usually given in the morning; then increase by 10-mg increments each week until a dose of 40 mg/day is reached. Maximum daily dose: 60 mg.
Obsessive-compulsive disorders.
Adults, initial: 20 mg/kg; then increase by 10-mg increments a day in intervals of at least 1 week until a dose of 40 mg/kg is reached. Maximum daily dose: 60 mg.
Social anxiety disorder.
Adults, initial: 20 mg/day, given as a single dose with or without food, usually in the morning. Dose range is 20-60 mg/day.
10-50 mg/day.
Diabetic neuropathy.
10-60 mg/day.
Premature ejaculation in men.
20 mg/day.

NOTE: Geriatric or debilitated clients, those with severe hepatic or renal impairment initial: 10 mg/day, up to a maximum of 40 mg/day for all uses.

?Tablets, Controlled Release Depression.
Adults, initial: 25 mg/day as a single daily dose with or without food, usually in the morning. If needed, increase the dose by 12.5 mg increments at intervals of 1 week or longer to a maximum of 62.5 mg/day. The initial dose for elderly or debilitated clients or those with severe renal or hepatic impairment is 12.5 mg/day; maintenance is not to exceed 50 mg/day.

Paroxetine hydrochloride Ratings

Overall Rating:



(based on 4 reviews)



Ease of Use:


Overall Satisfaction:




Paroxetine hydrochloride

Effectiveness: **

Ease of Use: **

Overall Satisfaction: ****


Vartan, Vartan - 01/14/2014

I have just recently cheeckd this website and I have found this website to be very useful and informative. Depression during pregnancy has now very wide-spread and is posing serious health issues. It is a well known fact that depression during can lead to abortion on early delivery of the child. The family of the pregnant woman must take vary special care of her and try to make her happy. They must also help her to overcome depression.

Paroxetine hydrochloride

Effectiveness: *****

Ease of Use: ***

Overall Satisfaction: ***


Ruth Miller, ma - 03/02/2010

Even though my depression seems to be coming along, the medications may be responsible for my fainting and joint pain.