Oxybutynin chloride Dosage, Interactions, Side Effects, How to Use


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Bladder Cancer   I was diagnosed with bladder cancer last week. I had surgery three days. Whar effect will this drug have with this condition? by Tom R. in Spring, Texas, 10/15/2009

Ingredients in Oxybutynin Chloride 5mg To whom it may concern, I am 48 years old. I have been taking Oxybutynin Chloride for several years now for Urinary Incontinence. It start after having my son at the age of 32, but was only precribed Oxybutinin a few years ago. Prescribed to me t... by Michelle Landry in Moncton, NB, Canada, 10/07/2009

side effect Constipation I have been taking ovybutybnin 10 mg for at least 3-4 months. I am constipated. So much so that I had to dig out the dry marbled pieces of stool! This has happened twice. Doctor sent me to a gastrologist and in Feb. I will get an upper and then 10 day... by Ruth Poore in Emmaus PA 18049, 01/24/2007

oxybutynin chloride I have been using this durg for several years and I jusT heard that it goes to the brain and causes serious memory problems. Some other drugs do not do this. I HAVE A PROBLEM WITH MY MEMORY. DOU KNOW OF THE RESEARCH THAT PROVES THIS PROBLEM AND WHAT S... by vernon in huntington sta. ny - usa, 12/20/2006

Oxybutynin 2.5 mgs Hi I was prescribed Oxybutynin 2.5mgs 1 x tds by my GP as I have presented with UTI symptoms but have a clear MSU. The symptoms disappeared for about 5 days but now are back again and I am wondering whether this is an adverse reaction to the tablets o... by Valerie in UK, 10/03/2006

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Oxybutynin chloride
Oxybutynin chloride (Ditropan)
Oxybutynin chloride
(ox-ee- BYOU-tih-nin)
Pregnancy Category: B Albert Oxybutynin Apo-Oxybutynin Ditropan Ditropan XL Gen-Oxybutynin Novo-Oxybutynin Nu-Oxybutyn Oxybutyn PMS-Oxybutynin (Rx)

Classification: Antispasmodic

Action/Kinetics: Causes increased vesicle capacity, decreases frequency of uninhibited contractions of the detrusor muscle, and delays initial urgency to void by exerting a direct antispasmodic effect. Has no effect at either the neuromuscular junction or autonomic ganglia. Has 4-10 times the antispasmodic effect of atropine but only one-fifth the anticholinergic activity. Onset: 30-60 min; Time to peak effect: 3-6 hr; duration: 6-10 hr. Eliminated through the urine.

Uses: Neurogenic bladder disease characterized by urinary retention, urinary overflow, incontinence, nocturia, urinary frequency or urgency, reflex neurogenic bladder.

Contraindications: Glaucoma (angle closure), untreated narrow anterior chamber angles, GI obstruction, paralytic ileus, intestinal atony (in elderly or debilitated), megacolon, toxic megacolon complicating ulcerative colitis, severe colitis, myasthenia gravis, obstructive uropathy, unstable CV status in acute hemorrhage.

Special Concerns: Use with caution when increased cholinergic effect is undesirable and in the elderly. Safe use in children less than 5 years of age has not been determined. Use with caution in geriatric clients; during lactation; in clients with autonomic neuropathy, renal, or hepatic disease; and in clients with hiatal hernia with reflex esophagitis. Heat stroke and fever (due to decreased sweating) may occur if given at high environmental temperatures.

Side Effects: GI: N&V, constipation, bloated feeling, decreased GI motility. CNS: Drowsiness, insomnia, weakness, dizziness, restlessness, hallucinations. EENT: Dry mouth, decreased lacrimation, mydriasis, amblyopia, cycloplegia. CV: Tachycardia, palpitations, vasodilation. Miscellaneous: Decreased sweating, urinary hesitancy and retention, impotence, suppression of lactation, severe allergic reactions drug idiosyncrasies, urticaria, and other dermal manifestations. NOTE: The drug may aggravate symptoms of prostatic hypertrophy, hypertension, coronary heart disease, CHF, hyperthyroidism, cardiac arrhythmias, and tachycardia.

Overdose Management: Symptoms: Intense CNS disturbances (restlessness, psychoses), circulatory changes (flushing, hypotension) and failure, respiratory failure, paralysis, coma. Treatment: Stomach lavage, physostigmine (0.5-2 mg IV; repeat as necessary up to maximum of 5 mg). Supportive therapy, if necessary. Counteract excitement with sodium thiopental (2%) or chloral hydrate (100-200 mL of 2% solution) rectally. Artificial respiration may be necessary if respiratory muscles become paralyzed.

Drug Interactions: See Cholinergic Blocking Agents.

How Supplied: Syrup: 5 mg/5 mL; Tablet: 5 mg; Tablet, Long-Acting: 5 mg, 10 mg, 15 mg

Dosage
?Syrup, Tablets
Adults: 5 mg b.i.d.-t.i.d. Maximum dose: 5 mg q.i.d. Children, over 5 years: 5 mg b.i.d. Maximum dose: 5 mg t.i.d.
?Tablets, Long-Acting
Adults, initial: 5 mg once daily. Increase, in 5- mg increments, up to a maximum of 30 mg/day.