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Oxacillin sodium
Oxacillin sodium (Bactocill)
Oxacillin sodium
(ox-ah-
SILL-in)
Pregnancy Category: B
Bactocill
(Rx)
Classification:
Antibiotic, penicillin
See Also:
See also
Anti-Infectives
[ and
Penicillins
][.
]
Action/Kinetics:
Penicillinase-resistant, acid-stable drug used for resistant staphylococcal infections.
Peak plasma levels: PO, 1.6-10 mcg after 30-60 min;
IM, 5-11 mcg/mL after 30 min.
t
1/2: 30 min.
Uses:
Infections caused by penicillinase-producing staphylococci; may be used to initiate therapy when a staphylococcal infection is suspected.
How Supplied:
Capsule: 250 mg, 500 mg;
Injection: 1 g/50 mL, 2 g/50 mL;
Powder for injection: 500 mg, 1 g, 2 g, 10 g;
Powder for reconstitution: 250 mg/5 mL
Dosage
?Capsules, Oral Solution
Mild to moderate infections of the upper respiratory tract, skin, soft tissue.
Adults and children (over 20 kg): 500 mg q 4-6 hr for at least 5 days.
Children less than 20 kg: 50 mg/kg/day in equally divided doses q 6 hr for at least 5 days.
Septicemia, deep-seated infections.
Parenteral therapy (see below) followed by PO therapy.
Adults: 1 g q 4-6 hr;
children: 100 mg/kg/day in equally divided doses q 4-6 hr.
?IM, IV
Mild to moderate infections.
Adults and children over 40 kg: 250-500 mg q 4-6 hr.
Children less than 40 kg: 50 mg/kg/day in equally divided doses q 6 hr.
Severe infections of the lower respiratory tract or disseminated infections.
Adults and children over 40 kg: 1 g q 4-6 hr.
Children less than 40 kg: 100 mg/kg/day in equally divided doses q 4-6 hr.
Neonates and premature infants, less than 2,000 g: 50 mg/kg/day divided q 12 hr if less than 7 days of age and 100 mg/kg/day divided q 8 hr if more than 7 days of age.
Neonates and premature infants, more than 2,000 g: 75 mg/kg/day divided q 8 hr if less than 7 days of age and 150 mg/kg/day divided q 6 hr if more than 7 days of age. Maximum daily dose:
Adults, 12 g;
children, 100-300 mg/kg. |
